| S8185 |
FPS-ZM1
|
FPS-ZM1是一種能透過血腦障壁、無毒性、三級酰胺化合物。是RAGE的特異性抑制劑，抑制Aβ與RAGE的V區(qū)域結(jié)合。 |
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Circ J, 2025, 10.1253/circj.CJ-24-0878
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Clin Immunol, 2024, 262:110178
-
Pharmacol Res, 2023, 192:106791
|
|
| S6415 |
Azeliragon (TTP488)
|
Azeliragon (TTP488, PF-04494700)是一種具有口服生物利用度的小分子抑制劑，抑制晚期糖基化終產(chǎn)物受體（RAGE）。RAGE是一種類免疫球蛋白細(xì)胞表面受體，在阿爾茨海默病患者的腦部過表達(dá)。 |
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Oncogene, 2025, 44(15):1051-1062
-
iScience, 2025, 28(8):113063
-
Circ J, 2025, 10.1253/circj.CJ-24-0878
|
|
| S3939 |
4'-Methoxyresveratrol
|
4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. |
|
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| S2422 |
Ipriflavone (Osteofix)
|
Ipriflavone (Osteofix)是小分子物質(zhì)，用于抑制骨吸收。 |
|
|
| S8185 |
FPS-ZM1
|
FPS-ZM1是一種能透過血腦障壁、無毒性、三級酰胺化合物。是RAGE的特異性抑制劑，抑制Aβ與RAGE的V區(qū)域結(jié)合。 |
- Circ J, 2025, 10.1253/circj.CJ-24-0878
- Clin Immunol, 2024, 262:110178
- Pharmacol Res, 2023, 192:106791
|
|
| S6415 |
Azeliragon (TTP488)
|
Azeliragon (TTP488, PF-04494700)是一種具有口服生物利用度的小分子抑制劑，抑制晚期糖基化終產(chǎn)物受體（RAGE）。RAGE是一種類免疫球蛋白細(xì)胞表面受體，在阿爾茨海默病患者的腦部過表達(dá)。 |
- Oncogene, 2025, 44(15):1051-1062
- iScience, 2025, 28(8):113063
- Circ J, 2025, 10.1253/circj.CJ-24-0878
|
|
| S3939 |
4'-Methoxyresveratrol
|
4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. |
|
|
| S2422 |
Ipriflavone (Osteofix)
|
Ipriflavone (Osteofix)是小分子物質(zhì)，用于抑制骨吸收。 |
|
|
