Recombinant Human Noggin Protein, CF (HEK293)

目錄號(hào): C0106

Recombinant Human Noggin Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln28-Cys232.

Recombinant Human Noggin Protein, CF (HEK293)on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

規(guī)格	價(jià)格	庫(kù)存
5ug	557	現(xiàn)貨
10ug	890	現(xiàn)貨
50ug	2570	現(xiàn)貨
400-668-6834 [email protected]

使用信息

物種

Human

標(biāo)簽

His tag at the C-terminus.

來(lái)源

HEK293-drived human Noggin protein Gln28-Cys232.

預(yù)測(cè)分子量

25.7 kDa

實(shí)際分子量

28-38 kDa, reducing conditions

純度

>95% as determined by Bis-Tris PAGE.

內(nèi)毒素

< 0.1 EU/ug by the LAL method

制劑

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

儲(chǔ)存條件 (自收到貨起)

For long-term storage, keep the product lyophilized at -20°C or below. Please avoid repeated freeze-thaw cycles. Stability:? Lyophilized: 12 months (-20°C to -80°C) Reconstituted: 3 months at -80°C under sterile conditions

生物描述

產(chǎn)品信息

Recombinant Human Noggin Protein (HEK293) 由 HEK293 表達(dá)，C 端帶有 His 標(biāo)簽。其包含 Gln28-Cys232。

Accession

Q13253-1

別名

Noggin, NOG, SYM1, SYNS1

背景

Noggin是骨形態(tài)發(fā)生蛋白(BMP)的拮抗劑，對(duì)某些發(fā)育事件至關(guān)重要。在胃癌細(xì)胞系模型和癌癥基因組圖譜人類(lèi)胃癌隊(duì)列中，Noggin的表達(dá)與EGFR的表達(dá)呈正相關(guān)。靶向EGFR及其下游通路可抑制Noggin促進(jìn)的細(xì)胞增殖。Noggin通過(guò)上調(diào)EGFR并增強(qiáng)β-catenin、EGFR、ERK和Akt形成的惡性循環(huán)來(lái)促進(jìn)胃癌細(xì)胞的增殖。

參考文獻(xiàn)

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