Recombinant Mouse IL-6 Protein, BSA (HEK293)

目錄號(hào): C0016

Recombinant Mouse IL-6 Protein is expressed from HEK293 with His tag at the N-terminus. It contains Phe25-Thr211.

Recombinant Mouse IL-6 Protein (HEK293) on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
Measured in a cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50?for this effect is 0.69 ng/mL.

規(guī)格	價(jià)格	庫存
100ug	5690	現(xiàn)貨
5ug	790	現(xiàn)貨
10ug	1270	現(xiàn)貨
50ug	3570	現(xiàn)貨
400-668-6834 [email protected]

使用信息

物種

Mouse

標(biāo)簽

His tag at the N-terminus.

來源

HEK293-drived mouse IL-6 protein Phe25-Thr211.

活性

Measured in a cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50?for this effect is 0.69 ng/mL.

預(yù)測分子量

23.6 kDa

實(shí)際分子量

25-30 kDa, reducing conditions

純度

>95% as determined by Bis-Tris PAGE.

內(nèi)毒素

< 0.1 EU/ug by the LAL method

制劑

Lyophilized from 0.22μm filtered solution in PBS with BSA as a carrier protein. Normally 8% trehalose is added as protectant before lyophilization.

儲(chǔ)存條件 (自收到貨起)

For long-term storage, keep the product lyophilized at -20°C or below. Please avoid repeated freeze-thaw cycles. Stability:? Lyophilized: 12 months (-20°C to -80°C) Reconstituted: 3 months at -80°C under sterile conditions

生物描述

產(chǎn)品信息

Recombinant Mouse IL-6 Protein (HEK293) 由 HEK293 表達(dá)，N 端帶有 His 標(biāo)簽。其包含 Phe25-Thr211。

Accession

P08505-1

別名

IFN-beta-2; IL6; IL-6; BSF-2; CDF; MGI-2A; Interleukin-6; HSF; IFNB2; HGF;IFN-β-2

背景

白細(xì)胞介素 6 (IL-6) 也稱為 HGF、BSF2、HSF、IFNB2 和 IL-6，最初被鑒定為 B 細(xì)胞分化因子，是一種多功能細(xì)胞因子，可調(diào)節(jié)免疫反應(yīng)、造血、急性期反應(yīng)和炎癥反應(yīng)。它由 T 細(xì)胞、巨噬細(xì)胞、單核細(xì)胞、成纖維細(xì)胞、內(nèi)皮細(xì)胞等分泌，以刺激對(duì)創(chuàng)傷（尤其是燒傷或其他導(dǎo)致炎癥的組織損傷）的免疫反應(yīng)。白細(xì)胞介素 6 已被證明與白細(xì)胞介素 6 受體和糖蛋白相互作用。IL-6 與許多疾病過程有關(guān)，例如糖尿病、動(dòng)脈粥樣硬化、抑郁癥、阿爾茨海默病、系統(tǒng)性紅斑狼瘡、前列腺癌和類風(fēng)濕性關(guān)節(jié)炎。晚期/轉(zhuǎn)移性癌癥患者血液中的 IL-6 水平較高。因此，開發(fā)抗 IL-6 藥物作為治療此類疾病的藥物具有很大前景。

參考文獻(xiàn)

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