| S1288 |
Camptothecin (CPT)
|
Camptothecin (CPT)是一種特異性的DNA拓撲異構酶I (Topo I)抑制劑,IC50為0.68 μM。Camptothecin 在癌細胞中可通過microRNA-125b介導的線粒體信號通路來誘導凋亡。Phase 2。 |
-
Cell Stem Cell, 2025, S1934-5909(25)00256-5
-
Nat Commun, 2025, 16(1):4491
-
EMBO J, 2025, 10.1038/s44318-025-00370-y
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|
| F0519 |
Argonaute-2 Antibody [E18J8]
|
AGO2,Ago2/eIF2C2,Argonaute 2,Argonaute-2,EIF2C2,RIPAb+ Ago2 - RIP Validated |
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| F0622 |
Argonaute 1 Antibody [G12M13]
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|
|
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| S3084 |
Guanosine 5'-triphosphate trisodium salt
|
Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt 是鼠細胞中成肌細胞分化的增強劑。Guanosine 5'-triphosphate trisodium salt 可上調miRNA(特別是miR133a和miR133b)和肌原性調節(jié)因子,并誘導人肌原性前體細胞在細胞外環(huán)境中釋放出被鳥苷基分子(主要是鳥苷)填充的外泌體。 |
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| E3687 |
Radix Actinidiae Extract
|
Radix Actinidiae Extract來源于藤梨根Radix Actinidiae,即獼猴桃Actinidia chinensis Planch.的根,可通過調控微小核糖核酸(miRNA)的表達發(fā)揮抗癌作用。 |
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| S3309 |
Solasodine
|
Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) 是一種存在于茄科植物中的有毒的生物堿化合物。Solaso??dine 可降低 matrix metalloproteinase-2 (MMP-2)、MMP-9 和 matrix metalloproteinase (EMMPRIN) 的細胞外誘導劑的mRNA水平,但會增加 reversion-inducing cysteine-rich protein with kazal motifs (RECK)。Solaso??dine 下調致癌的 microRNA-21 (miR-21),已知其靶向RECK。Solaso??dine 還可以減少 PI3K/Akt 信號傳導途徑并下調miR-21的表達。 |
|
|
| S9067 |
Pseudoprotodioscin
|
Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. |
|
|
| S9665 |
Motixafortide (BKT140)
|
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) 是一種 CXCR4 的拮抗劑,IC50值約為1 nM。BL-8040 通過改變的miR-15a/16-1的表達,下調 ERK、BCL-2、MCL-1 和 cyclin-D1,誘導AML胚的凋亡。 |
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King's College London, 2023,
|
|
| S1288 |
Camptothecin (CPT)
|
Camptothecin (CPT)是一種特異性的DNA拓撲異構酶I (Topo I)抑制劑,IC50為0.68 μM。Camptothecin 在癌細胞中可通過microRNA-125b介導的線粒體信號通路來誘導凋亡。Phase 2。 |
- Cell Stem Cell, 2025, S1934-5909(25)00256-5
- Nat Commun, 2025, 16(1):4491
- EMBO J, 2025, 10.1038/s44318-025-00370-y
|
|
| S3309 |
Solasodine
|
Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) 是一種存在于茄科植物中的有毒的生物堿化合物。Solaso??dine 可降低 matrix metalloproteinase-2 (MMP-2)、MMP-9 和 matrix metalloproteinase (EMMPRIN) 的細胞外誘導劑的mRNA水平,但會增加 reversion-inducing cysteine-rich protein with kazal motifs (RECK)。Solaso??dine 下調致癌的 microRNA-21 (miR-21),已知其靶向RECK。Solaso??dine 還可以減少 PI3K/Akt 信號傳導途徑并下調miR-21的表達。 |
|
|
| S9067 |
Pseudoprotodioscin
|
Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. |
|
|