| S7922 |
Tiplaxtinin (PAI-039)
|
Tiplaxtinin(PAI-039)是口服有效的選擇性纖溶酶原激活物抑制劑-1(PAI-1)抑制劑，IC50為2.7 μM。
|
-
Cell Death Dis, 2025, 16(1):529
-
Biomed Pharmacother, 2025, 189:118324
-
Int J Mol Sci, 2025, 26(1)401
|
|
| S3785 |
Notoginsenoside R1
|
Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways. |
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Food Sci Nutr, 2023, 11(12):7791-7802
-
J Ethnopharmacol, 2021, S0378-8741(21)00169-0
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|
| F0743 |
PAI-1 Antibody [J4H7]
|
PAI1,PAI-1,PAI-1/SERPINE1,Serpin E1/PAI-1 |
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| S9194 |
Toddalolactone
|
Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM. |
|
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| S3242 |
Loureirin B
|
Loureirin B (LB, LrB)，是從Dracaena cochinchinensis中提取的類黃酮，是 PAI-1 的抑制劑，其IC50值為26.10 μM。Loureirin B 可下調(diào)TGF-β1刺激的成纖維細胞中的 p-ERK 和 p-JNK。Loureirin B 主要通過增加Pdx-1、MafA、細胞內(nèi)ATP水平來促進胰島素分泌，抑制 KATP 電流，Ca2+ 進入細胞內(nèi)。 |
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| S6776 |
TM5275 Sodium
|
TM 5275 sodium 是一種口服的、生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制劑，其IC50值為6.95 μM。 |
|
|
| S6778 |
TM5441
|
TM5441是一種口服生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制劑，其IC50值介于9.7 μM 和60.3 μM 之間。TM5441可誘導幾種人類癌細胞系的內(nèi)源性細胞凋亡。 |
|
|
| S7922 |
Tiplaxtinin (PAI-039)
|
Tiplaxtinin(PAI-039)是口服有效的選擇性纖溶酶原激活物抑制劑-1(PAI-1)抑制劑，IC50為2.7 μM。
|
- Cell Death Dis, 2025, 16(1):529
- Biomed Pharmacother, 2025, 189:118324
- Int J Mol Sci, 2025, 26(1)401
|
|
| S3785 |
Notoginsenoside R1
|
Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways. |
- Food Sci Nutr, 2023, 11(12):7791-7802
- J Ethnopharmacol, 2021, S0378-8741(21)00169-0
|
|
| S9194 |
Toddalolactone
|
Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM. |
|
|
| S3242 |
Loureirin B
|
Loureirin B (LB, LrB)，是從Dracaena cochinchinensis中提取的類黃酮，是 PAI-1 的抑制劑，其IC50值為26.10 μM。Loureirin B 可下調(diào)TGF-β1刺激的成纖維細胞中的 p-ERK 和 p-JNK。Loureirin B 主要通過增加Pdx-1、MafA、細胞內(nèi)ATP水平來促進胰島素分泌，抑制 KATP 電流，Ca2+ 進入細胞內(nèi)。 |
|
|
| S6776 |
TM5275 Sodium
|
TM 5275 sodium 是一種口服的、生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制劑，其IC50值為6.95 μM。 |
|
|
| S6778 |
TM5441
|
TM5441是一種口服生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制劑，其IC50值介于9.7 μM 和60.3 μM 之間。TM5441可誘導幾種人類癌細胞系的內(nèi)源性細胞凋亡。 |
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|
