| S1218 |
Clofarabine
|
Clofarabine (Clolar)抑制 ribonucleotide reductase (RNR) (IC50 = 65 nM)和 DNA polymerase 的酶活性。Clofarabine 可誘導自噬和凋亡。 |
-
Invest Ophthalmol Vis Sci, 2025, 66(5):42
-
bioRxiv, 2025, 2025.04.25.650475
-
iScience, 2024, 27(10):110862
|
|
| S7470 |
Triapine (3-AP)
|
Triapine (3-AP) 是一種強效的ribonucleotide reductase (RNR)抑制劑，通過抑制DNA的合成而具有廣譜抗腫瘤活性。 |
-
iScience, 2024, 27(10):110862
-
Cancer Cell, 2023, 41(5):933-949.e11
-
J Virol, 2023, 97(8):e0026723
|
|
| S0283 |
COH-29
|
COH29 (RNR Inhibitor COH29) 是一種有效的 ribonucleotide reductase (RNR) 的抑制劑，具有抗癌活性。COH29 (RNR Inhibitor COH29) 在體外抑制重組 RNR small subunit (RRM1/RRM2) 的活性，對應的IC50值為16 μM。 |
-
Adv Sci (Weinh), 2021, e2100881
|
|
| S3385 |
NSAH
|
NSAH (HNASH)是一種可逆的、競爭性的非核苷核糖核苷酸還原酶 (ribonucleotide reductase, RNR)抑制劑，無細胞IC50為32 μM，基于細胞的IC50約為250 nM。 |
-
Pharmaceutics, 2022, 14-71387
|
|
| F0909 |
RRM1 Antibody [F10H22]
|
|
|
|
| S3641 |
Osalmid
|
Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM. |
|
|
| S1218 |
Clofarabine
|
Clofarabine (Clolar)抑制 ribonucleotide reductase (RNR) (IC50 = 65 nM)和 DNA polymerase 的酶活性。Clofarabine 可誘導自噬和凋亡。 |
- Invest Ophthalmol Vis Sci, 2025, 66(5):42
- bioRxiv, 2025, 2025.04.25.650475
- iScience, 2024, 27(10):110862
|
|
| S7470 |
Triapine (3-AP)
|
Triapine (3-AP) 是一種強效的ribonucleotide reductase (RNR)抑制劑，通過抑制DNA的合成而具有廣譜抗腫瘤活性。 |
- iScience, 2024, 27(10):110862
- Cancer Cell, 2023, 41(5):933-949.e11
- J Virol, 2023, 97(8):e0026723
|
|
| S0283 |
COH-29
|
COH29 (RNR Inhibitor COH29) 是一種有效的 ribonucleotide reductase (RNR) 的抑制劑，具有抗癌活性。COH29 (RNR Inhibitor COH29) 在體外抑制重組 RNR small subunit (RRM1/RRM2) 的活性，對應的IC50值為16 μM。 |
- Adv Sci (Weinh), 2021, e2100881
|
|
| S3385 |
NSAH
|
NSAH (HNASH)是一種可逆的、競爭性的非核苷核糖核苷酸還原酶 (ribonucleotide reductase, RNR)抑制劑，無細胞IC50為32 μM，基于細胞的IC50約為250 nM。 |
- Pharmaceutics, 2022, 14-71387
|
|
| S3641 |
Osalmid
|
Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM. |
|
|
