| S8893 |
Firsocostat (GS-0976, ND-630) |
Firsocostat (GS-0976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively. |
Pan |
hACC1, IC50: 2.1 nM |
| S8377 |
ND646 |
ND-646 is an allosteric inhibitor of the ACC (Acetyl-coA carboxylase) enzymes that prevents ACC subunit dimerization to suppress fatty acid synthesis with IC50 of 3.5 nM and 4.1 nM for hACC1 and hACC2, respectively. |
Pan |
hACC1, IC50: 3.5 nM |
| S6672 |
PF-05175157 |
PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively. |
Pan |
hACC1, IC50: 27.0 nM |
