DAT 選擇性抑制劑 | 調(diào)節(jié)劑
| 目錄號 |
產(chǎn)品名 |
產(chǎn)品描述 |
Selective / Pan |
IC50 / Ki |
| S6301 |
MPP+ iodide |
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. |
Selective |
|
| S3163 |
Benztropine mesylate |
Benztropine(Cogentin mesylate, Benztropine methanesulfonate) is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. |
Selective |
DAT, IC50: 118 nM |
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