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      • Lck
      • Fyn
      • Lyn
      • Yes
      • Fgr

      Fgr 抑制劑

      目錄號 產(chǎn)品名 產(chǎn)品描述 Selective / Pan IC50 / Ki
      S1006 Saracatinib (AZD0530) Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3. Pan FGR, IC50: 10 nM
      S8032 PRT062607 (P505-15) HCl PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70. Pan FGR, IC50: 81 nM
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