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NUDIX1 選擇性抑制劑

目錄號	產品名	產品描述	Selective / Pan	IC50 / Ki
S7631	TH287	TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.	Selective	MTH1, IC50: 0.8 nM
S7632	TH588	TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100?μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10?μM.	Selective	MTH1, IC50: 5 nM
S7505	(S)-crizotinib	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.	Selective	MTH1, IC50: 72 nM

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