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目錄號(hào)	產(chǎn)品名	產(chǎn)品描述	Selective / Pan	IC50 / Ki
S0078	1V209 (TLR7 agonist T7)	1V209 (T7, TLR7 agonist T7) is an agonist of Toll-like receptor 7 (TLR7) with anti-tumor effects. 1V209 can be used as vaccine adjuvants, enhances antigen specific humoral and cellular immune responses.	Selective
S0494	SM 324405	SM 324405 (compound 9e) is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 50 nM.	Selective	TLR7, EC50: 50 nM
S7221	Vesatolimod (GS-9620)	Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7.	Selective
S0716	E6446	E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro.	Pan
S9931	Enpatoran Hydrochloride	Enpatoran (M5049) hydrochloride is a potent, orally active, and dual TLR7/8 inhibitor with?IC50s of 11.1 nM and 24.1 nM, respectively, in HEK293 cells.	Pan	TLR7, IC50: 11.1 nM
S9623	Telratolimod	Telratolimod (3M-052, MEDI9197) is an agonist of toll-like receptor 7 (TLR-7) and toll-like receptor 8 (TLR-8) with antitumor activity.	Pan
S8133	Resiquimod (R-848)	Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2.	Pan
S4157	Chloroquine diphosphate	Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).	Pan

TLR7 選擇性抑制劑 | 激動(dòng)劑