Isoliquiritigenin

中文名稱：異甘草素

目錄號(hào)：S2404 Purity: 99.26%

Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一種類黃酮，能抑制醛糖還原酶，IC50為320 nM。具有抗腫瘤活性。

Isoliquiritigenin Chemical Structure

CAS: 961-29-5

規(guī)格	價(jià)格	庫(kù)存
10mM (1mL in DMSO)	1812.47	現(xiàn)貨
10mg	1415.93	現(xiàn)貨
50mg	4677.85	現(xiàn)貨
1g	22686.3	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次：純度： 99.26%

99.26

Isoliquiritigenin相關(guān)產(chǎn)品

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細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系	實(shí)驗(yàn)類型	給藥濃度	孵育時(shí)間	活性描述
MCF7 cells	Cytotoxicity assay	25-150 μM	72 h	Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay
U937 cells	Function assay	5 ug/ml	24 h	Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control
dog MDCK cells	Function assay	20 ug/mL	1 h	Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control
U937 cells	Function assay	5 ug/ml		Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control
J774.1 cells	Function assay		24 h	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM
colon 26-L5 cells	Cytotoxicity assay		72 h	Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM
human T47D cells	Function assay		96 h	Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay
MCF7 cells	Function assay		96 h	Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay
mouse NIH3T3 cells	Function assay		8 h	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM
OE21 cells	Cytotoxicity assay		72 h	Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM
dog MDCK cells	Function assay		8 h	Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence
HUVEC	Cytotoxicity assay		48 h	Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM
K562 cells	Cytotoxicity assay		48 h	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM
KB cells	Growth inhibition assay			Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM
MT-4 cells	Growth inhibition assay			Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM
Hepa lclc7 cells	Cytotoxicity assay			Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM
CHO cells	Cytotoxicity assay			Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM
MCF7 cells	Function assay			Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay
NCI-H292 cells	Function assay			Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis
NCI-H292 cells	Function assay			Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis
NCI-H292 cells	Function assay			Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis
dog MDCK cells	Function assay			Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay
RBL-1 cells	Function assay			In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM
PC3 cells	Cytotoxicity assay			Cytotoxicity against human PC3 cells, IC50=46.4 μM
Hepa-1c1c7 cells	Function assay			Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity
Hepa lclc7 cells	Function assay			Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity
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生物活性

產(chǎn)品描述

Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一種類黃酮，能抑制醛糖還原酶，IC50為320 nM。具有抗腫瘤活性。

靶點(diǎn)

Aldose reductase ^[1]
(Cell-free assay)

320 nM

體外研究(In Vitro)
體外研究活性	Isoliquiritigenin通過抑制大鼠晶狀體醛糖還原酶可能能夠有效預(yù)防糖尿病并發(fā)癥，IC50為320 nM，并且能夠預(yù)防山梨糖醇在人類紅細(xì)胞中的積累，IC50為2.0 μM。^[1] Isoliquiritigenin通過抑制單酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白劑，IC50為8.1 μM。^[2] 在DU145和LNCaP 細(xì)胞系中，Isoliquiritigenin誘導(dǎo)細(xì)胞周期停滯并抑制細(xì)胞生長(zhǎng)。^[3]在人類胃癌MGC-803細(xì)胞中， Isoliquiritigenin通過增加細(xì)胞內(nèi)游離鈣離子濃度，并降低線粒體膜電位(Deltapsi(m))而誘導(dǎo)細(xì)胞凋亡。^[4]

體內(nèi)研究(In Vivo)
體內(nèi)研究活性	LD50: 小鼠>6克/千克(灌胃) ^[5]

參考文獻(xiàn)
[1]https://pubmed.ncbi.nlm.nih.gov/2118267/ [2]https://pubmed.ncbi.nlm.nih.gov/12590456/ [3]https://pubmed.ncbi.nlm.nih.gov/12706007/ [4]https://pubmed.ncbi.nlm.nih.gov/11731922/ [5]https://pubmed.ncbi.nlm.nih.gov/19067384/ + 展開

參考文獻(xiàn)

[1]https://pubmed.ncbi.nlm.nih.gov/2118267/
[2]https://pubmed.ncbi.nlm.nih.gov/12590456/
[3]https://pubmed.ncbi.nlm.nih.gov/12706007/

[4]https://pubmed.ncbi.nlm.nih.gov/11731922/
[5]https://pubmed.ncbi.nlm.nih.gov/19067384/

+ 展開

化學(xué)信息&溶解度

分子量	256.25	分子式	C₁₅H₁₂O₄
CAS號(hào)	961-29-5	SDF	Download Isoliquiritigenin SDF
Smiles	C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

Ethanol : 26 mg/mL (101.46 mM)

DMSO : 12 mg/mL ( (46.82 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

DMSO : 51 mg/mL ( (199.02 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 26 mg/mL (101.46 mM)

Water : Insoluble

DMSO : 51 mg/mL ( (199.02 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Ethanol : 51 mg/mL (199.02 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解配方批次：現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑				動(dòng)物體內(nèi)配方計(jì)算器
均勻懸濁液	CMC-NA	≥5mg/ml	以 1 mL 工作液為例，取 5 mg該產(chǎn)品加到 1 ml CMC-NA 溶液中，混合均勻，即可得工作液濃度為 5 mg/ml的均勻懸濁液。
均勻懸濁液	CMC-NA	≥5mg/ml	以 1 mL 工作液為例，取 5 mg該產(chǎn)品加到 1 ml CMC-NA 溶液中，混合均勻，即可得工作液濃度為 5 mg/ml的均勻懸濁液。
均勻懸濁液	CMC-NA	≥5mg/ml	以 1 mL 工作液為例，取 5 mg該產(chǎn)品加到 1 ml CMC-NA 溶液中，混合均勻，即可得工作液濃度為 5 mg/ml的均勻懸濁液。
澄清溶液	5%DMSO 1 Corn oil 該配方已經(jīng)過Selleck實(shí)驗(yàn)室實(shí)測(cè)。如果上述溶解方案不能滿足您的需求，可聯(lián)系Selleck銷售提供定制化測(cè)試。	0.250mg/ml (0.98mM)	以 1 mL 工作液為例，取50μL5mg/ml的澄清DMSO儲(chǔ)備液加到950μL玉米油中，混合均勻。工作液請(qǐng)現(xiàn)配現(xiàn)用！
澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O 該配方已經(jīng)過Selleck實(shí)驗(yàn)室實(shí)測(cè)。如果上述溶解方案不能滿足您的需求，可聯(lián)系Selleck銷售提供定制化測(cè)試。	2.500mg/ml (9.76mM)	以 1 mL 工作液為例,取50μL50mg/ml的澄清DMSO儲(chǔ)備液加到400μLPEG300中,混合均勻使其澄清;向上述體系中加入50μLTween80,混合均勻使其澄清;然后繼續(xù)加入500μLddH2O定容至1mL。工作液請(qǐng)現(xiàn)配現(xiàn)用!

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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