CXCR1 選擇性抑制劑 | 拮抗劑
| 目錄號 |
產(chǎn)品名 |
產(chǎn)品描述 |
Selective / Pan |
IC50 / Ki |
| S8640 |
Reparixin (Repertaxin) |
Reparixin (Repertaxin, DF 1681Y) is a potent and specific inhibitor of CXCR1 with IC50 of 1 nM. Reparixin (Repertaxin) inhibits PMN migration induced by CXCL8 (IC50 = 1 nM) and rodent PMN chemotaxis induced by CXCL1 and CXCL2. Repertaxin inhibits the response of human PMN to CXCL1, which interacts with CXCR2 (IC50 = 400 nM). |
Selective |
CXCR1, IC50: 1 nM |
| S8947 |
SX-682 |
SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity. |
Pan |
|
| S8506 |
Navarixin (SCH-527123) |
Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively. |
Pan |
CXCR1, IC50: 36 nM |
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