| S1531 |
BIX 02189 |
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
Selective |
ERK5, IC50: 59 nM |
| S7525 |
XMD8-92 |
XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with Kd of 80 nM and 170 nM for ERK5 and BRD4(1), respectively. |
Selective |
BMK1, Kd: 80 nM |
| S7334 |
ERK5-IN-1 |
ERK5-IN-1 (XMD17-109) is a potent, and selective ERK5 inhibitor with IC50 of 162 nM.
|
Selective |
ERK5, IC50: 162 nM |
| S6786 |
ERK5-IN-2 |
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50 of 0.82 μM and 3 μM for ERK5 and ERK5 MEF2D, respectively. |
Selective |
ERK5, IC50: 0.82 μM; ERK5 MEF2D, IC50: 3 μM |
| S8896 |
BAY-885 |
BAY-885 is a highly potent and selective ERK5 inhibitor. |
Selective |
|
| S0726 |
XMD8-85 (ERK5-IN-1) |
XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. |
Selective |
|
