| S5926 |
Pitolisant hydrochloride |
Pitolisant (Tiprolisant, BF-2649) acts as a high-affinity competitive antagonist (Ki=0.16 nM) and as an inverse agonist (EC50=1.5 nM) at the human histamine H3 receptor subtype. |
Selective |
H3 receptor, Ki: 0.16 nM |
| S2813 |
Ciproxifan Maleate |
Ciproxifan (FUB 359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
Selective |
Histamine H3 receptor, IC50: 9.2 nM |
| S8598 |
S 38093 |
S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.
|
Selective |
rat H3 receptor, Ki: 8.8 μM; mouse H3 receptor, Ki: 1.44 μM; human H3 receptor, Ki: 1.2 μM |
| S3176 |
Betahistine 2HCl |
Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1.9 μM. |
Selective |
Histamine H3 receptor, IC50: 1.9 μM |
