| S7803 |
GSK484 HCl |
GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 50 nM in the absence of Calcium. |
Selective |
PAD4, IC50: 50 nM |
| S9644 |
BMS-P5 |
BMS-P5, a potent selective pharmacological inhibitor of PAD4, is used to evaluate the effect of PAD4 inhibition on multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation. |
Selective |
PAD4, IC50: 98 nM |
| S8141 |
Cl-amidine |
Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis. |
Pan |
PAD4, IC50: 5.9 μM |
