| S7573 |
GSK2830371 |
GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
|
Selective |
Wip1 phosphatase, IC50: 6 nM |
| S0744 |
Raphin1 acetate |
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM. |
Selective |
R15B-PP1c, Kd: 0.033 μM |
| S0528 |
Raphin1 |
Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM. |
Selective |
R15B-PP1c, Kd: 33 nM |
| S5452 |
Sanguinarine chloride |
Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. |
Selective |
PP2C, Ki: 0.68 μM |
| S7485 |
CCT007093 |
CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
Selective |
PPM1D, IC50: 8.4 μM |
| S7437 |
Sal003 |
Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
Selective |
|
