WDR5-MLL-interaction 抑制劑 | 拮抗劑
| 目錄號 |
產(chǎn)品名 |
產(chǎn)品描述 |
Selective / Pan |
IC50 / Ki |
| S7265 |
MM-102 |
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1 protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM. |
Pan |
WDR5, IC50: 2.4 nM |
| S7833 |
OICR-9429 |
OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM. |
Pan |
WDR5, Kd: 93 nM |
| S2184 |
WDR5-0103 |
WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM. |
Pan |
WDR5, Kd: 450 nM; WDR5-MLL interaction, : |
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