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                        Abl
                    
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                        c-Abl
                    
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                        v-Abl
                    
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      c-Abl 抑制劑
      
        
      
            
            
      
                目錄號(hào)
                產(chǎn)品名
                產(chǎn)品描述
                Selective / Pan
                IC50 / Ki
            
      
                  
            
            
                
      
                    S9973
                    Flumatinib (HH-GV-678)
                    
      Flumatinib (HH-GV-678) is a novel inhibitor of Bcr-Abl with IC50 values of 1.2  nM, 307.6  nM and 665.5  nM for c-Abl, PDGFRβand c-Kit, respectively.
      
      		
                    Pan
                    c-Abl, IC50: 1.2 nM
                
      
            
                
      
                    S8140
                    GNF-7
                    GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively. 

                    Pan
                    c-Abl, IC50: 133 nM
                
      
            
                
      
                    S2642
                    1-Naphthyl PP1(1-NA-PP1)
                    1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of  154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
                    Pan
                    c-Abl, IC50: 0.6 μM
                
      
            
                
      
                    S2202
                    NVP-BHG712
                    NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
                    Pan
                    c-Abl, IC50: 1.667 μM
                
      
            
                
      
                    S6662
                    AST-487 (NVP-AST487)
                    AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
                    Pan
                    
                
      
            
                  
        
      
        
    
      

      
    







      


      
    
    
    
    
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