| S3245 |
Nodakenetin |
Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity. |
Selective |
|
| S3839 |
1-Deoxynojirimycin |
1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
Selective |
|
| S6921 |
Dorzagliatin |
Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes. |
Selective |
|
| S2155 |
LY2608204 |
LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2. |
Selective |
glucokinase , EC50: 42 nM |
| S3527 |
AM2394 |
AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM. |
Selective |
GK, EC50: 60 nM |
| S0553 |
Butyl isobutyl phthalate |
Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment. |
Selective |
α-glucosidase, IC50: 38 μM |
