| S7686 |
ML141 |
ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis. |
Selective |
cdc42, IC50: 200 nM |
| S6000 |
CID44216842 |
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively. |
Selective |
Cdc42 WT, EC50: 1.0 μM; Cdc42 Q61L, IC50: 1.2 μM |
| S5996 |
MLS-573151 |
MLS-573151 is a selective cell division cycle 42 (Cdc42) inhibitor with an EC50 of 2 μM, which acts by blocking the binding of GTP to Cdc42. |
Selective |
Cdc42, EC50: 2 μM |
| S7293 |
ZCL278 |
ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
Selective |
Cdc42 GTPase, Kd: 11.4 μM |
| S8749 |
MBQ-167 |
MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells. |
Pan |
cdc42, IC50: 78 nM |
