| S8812 |
CM272 |
CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8?nM, 382 nM, 85 nM, 1200 nM, 2?nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. |
Pan |
DNMT3A, IC50: 85 nM; DNMT3B, IC50: 1200 nM |
| S7276 |
SGI-1027 |
SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI?1027 induces apoptosis. |
Pan |
DNMT3A, IC50: 8 μM; DNMT3B, IC50: 7.5 μM |
