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2',3'-cGAMP Sodium Salt
別名: 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium
2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是響應(yīng)哺乳動物細(xì)胞質(zhì)中的DNA產(chǎn)生的，并能以高親和力結(jié)合 STING，且有效地誘導(dǎo) interferon-β (IFNβ)。2',3'-cGAMP 結(jié)合 STING 的Kd值為3.79 nM。
2',3'-cGAMP Sodium Salt Chemical Structure
CAS: 2734858-36-5
產(chǎn)品質(zhì)控
批次：
純度：
99.83%
99.83
常與2',3'-cGAMP Sodium Salt一起在實(shí)驗(yàn)中被使用的化合物
2',3'-cGAMPSodiumSalt和3',3'-cGAMP均能成熟的人單核細(xì)胞來源的DC，上調(diào)CD40/CD80/CD86/HLA-DR標(biāo)記物水平。
diABZI STING agonist-1 (tautomerism)
2',3'-cGAMP Sodium Salt和diABZI STING agonist (Compound 3)具有最有效的廣譜抗病毒功能。
2',3'-cGAMP Sodium Salt相關(guān)產(chǎn)品
| 相關(guān)產(chǎn)品 | C-176 CCCP diABZI STING agonist-1 (tautomerism) H-151 STING inhibitor C-178 C-171 G10 (STING agonist-1) MSA-2 | 點(diǎn)擊展開 |
|---|---|---|
| 相關(guān)化合物庫 | 激酶抑制劑庫 FDA藥物庫 天然產(chǎn)物庫 已知活性藥物庫-I 高選擇性抑制劑庫 | 點(diǎn)擊展開 |
細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例
| 細(xì)胞系 | 實(shí)驗(yàn)類型 | 給藥濃度 | 孵育時間 | 活性描述 | 文獻(xiàn)信息(PMID) |
|---|---|---|---|---|---|
| PBMC | Function assay | 69.6 uM | 4 hrs | Agonist activity at STING in human PBMC cells assessed as increase in CXCL10 mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis | 31820985 |
| PBMC | Function assay | 1.39 to 139 uM | 4 hrs | Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta release at 1.39 to 139 uM measured after 4 hrs by ELISA | 31820985 |
| PBMC | Function assay | 69.6 uM | 4 hrs | Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis | 31820985 |
| PBMC | Function assay | 69.6 uM | 4 hrs | Agonist activity at STING in human PBMC cells assessed as increase in IL6 mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis | 31820985 |
| PBMC | Function assay | 139 uM | 4 hrs | Agonist activity at STING in human PBMC cells assessed as increase in IL6 production at 139 uM measured after 4 hrs by ELISA | 31820985 |
| 293T | Function assay | 30 mins | Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.02 μM. | 31715099 | |
| 293T | Function assay | 30 mins | Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.02 μM. | 31715099 | |
| 293T | Function assay | 30 mins | Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.04 μM. | 31715099 | |
| 293T | Function assay | 30 mins | Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.05 μM. | 31715099 | |
| 293T | Function assay | 30 mins | Activation of recombinant human STING haplotype R232H mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.07 μM. | 31715099 | |
| 293T | Function assay | 7 hrs | Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 13.7 μM. | 31715099 | |
| THP1 | Function assay | 20 hrs | Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assay, EC50 = 38.6 μM. | 31820985 | |
| B16-OVA | Antitumor assay | Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as tumour regression in injected flank at 10 ug administered intratumorally on day 6, 9 and 12 post implantation | 31500996 | ||
| B16-OVA | Antitumor assay | Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as tumour regression in contralateral flank at 10 ug administered intratumorally on day 6, 9 and 12 post implantation | 31500996 | ||
| B16-OVA | Antitumor assay | Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as higher number of mouse cured of tumors at 10 ug administered intratumorally on day 6, 9 and 12 post implantation | 31500996 | ||
| 點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù) | |||||
生物活性
| 產(chǎn)品描述 | 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是響應(yīng)哺乳動物細(xì)胞質(zhì)中的DNA產(chǎn)生的，并能以高親和力結(jié)合 STING，且有效地誘導(dǎo) interferon-β (IFNβ)。2',3'-cGAMP 結(jié)合 STING 的Kd值為3.79 nM。 | ||
|---|---|---|---|
| 靶點(diǎn) |
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化學(xué)信息&溶解度
| 分子量 | 718.37 | 分子式 | C20H22N10Na2O13P2 |
| CAS號 | 2734858-36-5 | SDF | -- |
| 密度 | g/mL | ||
| 儲存條件(自收到貨起) | 3年 -20°C 粉狀 | ||
|
體外溶解度 |
DMSO : 100 mg/mL ( (139.2 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO) Water : 100 mg/mL (139.2 mM) Ethanol : Insoluble |
摩爾濃度計算器 |
|
體內(nèi)溶解配方 現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動物體內(nèi)配方計算器 | |||||
實(shí)驗(yàn)計算
動物體內(nèi)配方計算器（澄清溶液）
第一步：請輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動物的藥量）
mg/kg
g
μL
只
第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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