| S6433 |
Udenafil |
Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. |
Pan |
PDE2, IC50: 101 nM |
| S4837 |
Ibudilast |
Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities. |
Pan |
PDE2, IC50: 0.11 μM |
| S2484 |
Milrinone |
Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility. |
Pan |
PDE2, IC50: 5.2 μM |
| S2320 |
Luteolin |
Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. |
Pan |
PDE2, Ki: 6.4 μM |
| S5539 |
Olprinone |
Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively. |
Pan |
PDE2, IC50: 100 mM |
