Cholinesterase (ChE)

Cholinesterase (ChE)產(chǎn)品

所有產(chǎn)品(54)
Cholinesterase (ChE)抑制劑 (36)
Cholinesterase (ChE)激活劑 (1)
Cholinesterase (ChE)拮抗劑 (3)
Cholinesterase (ChE)激動劑 (2)
Cholinesterase (ChE)調(diào)節(jié)劑 (1)
新Cholinesterase (ChE)產(chǎn)品

目錄號	產(chǎn)品名	產(chǎn)品描述	文獻(xiàn)引用
S2462	Donepezil HCl	Donepezil HCl 是一種特異性的，有效的AChE抑制劑，作用于bAChE和hAChE，IC50分別為8.12 nM和11.6 nM。此產(chǎn)品不溶于PBS，請勿用PBS溶解給藥。	Sci Adv, 2025, 11(14):eads7191 Theranostics, 2023, 13(6):1826-1842 J Cell Physiol, 2023, 10.1002/jcp.31057
S3809	Imperatorin	Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.	Pharmaceuticals (Basel), 2023, 10.3390/ph16111595 Metabolites, 2022, 13(1)3 Adv Sci (Weinh), 2020, 7(16):2000925
S1890	Nizatidine	Nizatidine是一種組胺H2受體拮抗劑，作用于AChE，IC50為6.7 nM。	Gastroenterology, 2022, 162(4):1210-1225 Calcif Tissue Int, 2021, 109(6):696-705 bioRxiv, 2021, 10.1101/2021.04.29.441931
S5073	Donepezil	Donepezil (Aricept, Donepezilo)是一種有效的、可逆的、特異的和非競爭性acetylcholinesterase (AChE)抑制劑，用于治療輕度至中度癡呆。	Cell Biosci, 2024, 14(1):146 Theranostics, 2023, 13(6):1826-1842 Front Bioeng Biotechnol, 2022, 10:855755
S2087	Rivastigmine Tartrate	Rivastigmine Tartrate (ENA 713) 是一種膽堿酯酶抑制劑，IC50為5.5 μM，作為副交感神經(jīng)或膽堿能劑，用于治療輕度至中度阿爾茨海默病。	J Cell Physiol, 2023, 10.1002/jcp.31057 Mol Psychiatry, 2018, 23(3):767-776
S2251	(-)-Huperzine A (HupA)	(-)-Huperzine A (HupA)是一種有效的，高度特異性的，可逆acetylcholinesterase (AChE)（乙酰膽堿酯酶）抑制劑，K_i為7 nM，作用于G4 AChE比作用于G1 AChE選擇性高200倍。Phase 4。	Acta Pharmacol Sin, 2019, 10.1038/s41401-018-0206-4
S1339	Galanthamine HBr	Galanthamine HBr是一種AChE抑制劑，IC50為0.35 μM，比作用于丁酰膽堿酯酶選擇性高50倍。	J Cell Physiol, 2023, 10.1002/jcp.31057
S1608	Pyridostigmine Bromide	Pyridostigmine Bromide 是一種擬副交感神經(jīng)的和可逆的膽堿酯酶抑制劑。	J Immunother Cancer, 2024, 12(11)e009805 J Am Heart Assoc, 2014, 3(3):e000804
S2490	Neostigmine Bromide	Neostigmine Bromide 是一種可逆的膽堿酯酶抑制劑。	Am J Physiol Gastrointest Liver Physiol, 2016, 310(3):G181-92
S5900	Edrophonium chloride	Edrophonium chloride是edrophonium的氯鹽形式。Edrophonium是一種快速起效、短效、易可逆的acetylcholinesterase (乙酰膽堿酯酶)抑制劑。	Front Mol Biosci, 2024, 11:1423351 Int J Mol Sci, 2023, 10.3390/ijms242115535
S9290	Linarin	Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects.	Front Pharmacol, 2020, 11:582520
S4687	Rivastigmine	Rivastigmine (SDZ-ENA 713, Exelon) 是一種膽堿酯酶的抑制劑，IC50為5.5 μM。它抑制乙酰膽堿酯酶（IC50=4.15 μM）和丁酰膽堿酯酶（IC50=37 nM）。	Front Mol Biosci, 2024, 11:1423351 Nature, 2018, 560(7718):372-376
S3866	Galanthamine	Galanthamine (Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.
S3235	Sinapine	Sinapine 是一種從十字花科物種的種子中分離出來的生物堿，具有抗氧化、抗腫瘤和放射防護(hù)的作用。Sinapine 通過下調(diào) P-glycoprotein 來抑制Caco-2細(xì)胞的增殖。	Gene, 2022, 827:146460
S4575	Pralidoxime chloride	Pralidoxime chloride (2-PAM)是有機(jī)磷農(nóng)藥和一些化學(xué)制品的解毒劑。是AChE的重新激活劑。
E7226	Pirimiphos-methyl	Pirimiphos-methyl 是一種快速作用的有機(jī)磷殺蟲劑和殺螨劑，可抑制目標(biāo)生物體中的乙酰膽堿酯酶 (AChE)。Pirimiphos-methyl 經(jīng)常在農(nóng)業(yè)谷物的儲存過程中用于預(yù)防和控制甲蟲，鼻子甲蟲，飛蛾和埃氏小球藻。
S0924	Pteryxin	Pteryxin ((+)-Pteryxin) 是一種在 Apiaceae 傘形科中發(fā)現(xiàn)的二氫吡喃香豆素衍生物，也是一種有效的 butyrylcholinesterase (BChE) 的抑制劑，IC50值為12.96 μg/ml。Pteryxin 可抑制LPS誘導(dǎo)的小鼠腹膜巨噬細(xì)胞中 nitric oxide 的產(chǎn)生，其IC50值為20 μM。Pteryxin 具有治療阿爾茨海默氏病 (AD) 的潛力。
S9219	Huperzine B	Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.
S5886	Hodostin	Hodostin (Neostigmine methyl sulfate, Syntostigmin, Neostigmeth) 是acetylcholinesterase (AChE)的可逆性抑制劑，不能穿透血腦屏障，用于治療重癥肌無力。
S3246	Picfeltarraenin IB	Picfeltarraenin IB 是從 Picriafel-terrae 中分離出的葫蘆素糖苷，是 acetylcholinesterase (AChE) 的抑制劑。Picfeltarraenin IB 可用于治療皰疹感染，癌癥和炎癥。
S5663	Minaprine dihydrochloride	Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.
S9252	Corydaline	Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.
S5665	Drofenine Hydrochloride	Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers.
S9257	Acetylshikonin	Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.
S9260	Nodakenin	Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.
S3835	Loganin	Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
S4619	Itopride hydrochloride	Itopride hydrochloride (Ganaton, HSR803) 是一種AChE抑制劑。其IC50為2.04 +/- 0.27 μM。
S9463	Demecarium Bromide	Demecarium Bromide 是一種抗膽堿酯酶藥物，是單胺氧化酶 (MAO) 的抑制劑。它會引起長期瞳孔縮小，并降低血壓正常的比格犬和患有遺傳性青光眼的比格犬的眼睛的眼壓 (IOP)。
S3701	Benactyzine hydrochloride	Benactyzine hydrochloride是中樞性毒蕈堿受體拮抗劑。在抑郁癥和相關(guān)焦慮的治療中，它被用作抗抑郁劑。
S4972	Choline Glycerophosphate	Choline Glycerophosphate (Glycerophosphorylcholine) 是膽堿衍生物，是胞漿中兩種主要的膽堿儲存形式之一。
S3639	Tacrine hydrochloride hydrate	Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) 是膽堿酯酶（cholinesterase）抑制劑，可對抗骨骼肌松弛藥的作用，可作為呼吸興奮劑并用于治療阿茲海默病和其他中樞神經(jīng)系統(tǒng)障礙。它也是組胺N-甲基轉(zhuǎn)移酶（histamine N-methyltransferase）抑制劑。
S4072	Decamethonium Bromide	Decamethonium Bromide是一種煙堿AChR部分激動劑和神經(jīng)肌肉阻斷劑。
S3769	Palmatine	Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.	Eur J Pharmacol, 2024, 967:176395
S9069	Jatrorrhizine chloride	Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
S9386	Polygalacic acid	Polygalacic acid 是從遠(yuǎn)志屬植物（Polygala paenea L.）分離出的三萜類四羥酸。Polygalacic acid (0-100μM; 24h) 可以顯著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表達(dá)，這些因子的表達(dá)由IL-1β誘導(dǎo)可顯著增加，并呈現(xiàn)出劑量依賴性。
S9085	Corynoline	Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.
S9087	Tenuifolin	Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.	CNS Neurosci Ther, 2025, 31(8):e70588
E7361	(±)-Huperzine A	(±)-Huperzine A 是傳統(tǒng)中草藥中提取的活性石松屬生物堿，是可逆的乙酰膽堿酯酶（ACE）抑制劑，在中國被廣泛的運用于阿爾茨海默病。
S4804	1-Naphthyl acetate	1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages.
S3881	Scopoletin	Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.	Biochem Biophys Rep, 2025, 42:102021
S3884	Jatrorrhizine	Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
S3704	4-Methylbenzylidene camphor	4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
S9108	Timosaponin A3	Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity.
S5085	Azamethiphos	Azamethiphos是有機(jī)磷酸酯殺蟲劑，用于治療養(yǎng)殖大馬哈魚的海虱感染。
E0905	N-p-trans-Coumaroyltyramine	N-p-trans-Coumaroyltyramine is an alpha-glucosidase inhibitor.
S3904	Isoimperatorin	Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities.
S9138	Picfeltarraenin IA	Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
S9152	Epiberberine	Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
S9510	Protriptyline hydrochloride	Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake.
S4521	DEET	DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) 是一種常見的殺蟲劑的活性成分。
S4838	Acotiamide hydrochloride	Acotiamide Hydrochloride (YM-443, Z-338)是acotiamide的鹽酸形式，acotiamide是一種腸蠕動促進(jìn)劑。它是一種新型的、具有口服活性的、選擇性的AChE抑制劑。
S9178	Sinapine thiocyanate	Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.	Gene, 2022, 827:146460
S5868	DL-Menthol	DL-Menthol是D-和L-menthol的外消旋混合物。Menthol是一種共價有機(jī)化合物，可通過有機(jī)反應(yīng)合成或從薄荷油中提取。
E5819^New	Clozapine N-oxide dihydrochloride	Clozapine N-oxide dihydrochloride 是氯氮平的主要代謝產(chǎn)物。它可作為人類毒蕈堿受體 DREADD 的激動劑，對 M1 DREADD 的 pEC50 為 8.31。
S2462	Donepezil HCl	Donepezil HCl 是一種特異性的，有效的AChE抑制劑，作用于bAChE和hAChE，IC50分別為8.12 nM和11.6 nM。此產(chǎn)品不溶于PBS，請勿用PBS溶解給藥。	Sci Adv, 2025, 11(14):eads7191 Theranostics, 2023, 13(6):1826-1842 J Cell Physiol, 2023, 10.1002/jcp.31057
S5073	Donepezil	Donepezil (Aricept, Donepezilo)是一種有效的、可逆的、特異的和非競爭性acetylcholinesterase (AChE)抑制劑，用于治療輕度至中度癡呆。	Cell Biosci, 2024, 14(1):146 Theranostics, 2023, 13(6):1826-1842 Front Bioeng Biotechnol, 2022, 10:855755
S2087	Rivastigmine Tartrate	Rivastigmine Tartrate (ENA 713) 是一種膽堿酯酶抑制劑，IC50為5.5 μM，作為副交感神經(jīng)或膽堿能劑，用于治療輕度至中度阿爾茨海默病。	J Cell Physiol, 2023, 10.1002/jcp.31057 Mol Psychiatry, 2018, 23(3):767-776
S2251	(-)-Huperzine A (HupA)	(-)-Huperzine A (HupA)是一種有效的，高度特異性的，可逆acetylcholinesterase (AChE)（乙酰膽堿酯酶）抑制劑，K_i為7 nM，作用于G4 AChE比作用于G1 AChE選擇性高200倍。Phase 4。	Acta Pharmacol Sin, 2019, 10.1038/s41401-018-0206-4
S1339	Galanthamine HBr	Galanthamine HBr是一種AChE抑制劑，IC50為0.35 μM，比作用于丁酰膽堿酯酶選擇性高50倍。	J Cell Physiol, 2023, 10.1002/jcp.31057
S1608	Pyridostigmine Bromide	Pyridostigmine Bromide 是一種擬副交感神經(jīng)的和可逆的膽堿酯酶抑制劑。	J Immunother Cancer, 2024, 12(11)e009805 J Am Heart Assoc, 2014, 3(3):e000804
S2490	Neostigmine Bromide	Neostigmine Bromide 是一種可逆的膽堿酯酶抑制劑。	Am J Physiol Gastrointest Liver Physiol, 2016, 310(3):G181-92
S5900	Edrophonium chloride	Edrophonium chloride是edrophonium的氯鹽形式。Edrophonium是一種快速起效、短效、易可逆的acetylcholinesterase (乙酰膽堿酯酶)抑制劑。	Front Mol Biosci, 2024, 11:1423351 Int J Mol Sci, 2023, 10.3390/ijms242115535
S4687	Rivastigmine	Rivastigmine (SDZ-ENA 713, Exelon) 是一種膽堿酯酶的抑制劑，IC50為5.5 μM。它抑制乙酰膽堿酯酶（IC50=4.15 μM）和丁酰膽堿酯酶（IC50=37 nM）。	Front Mol Biosci, 2024, 11:1423351 Nature, 2018, 560(7718):372-376
S3866	Galanthamine	Galanthamine (Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.
S3235	Sinapine	Sinapine 是一種從十字花科物種的種子中分離出來的生物堿，具有抗氧化、抗腫瘤和放射防護(hù)的作用。Sinapine 通過下調(diào) P-glycoprotein 來抑制Caco-2細(xì)胞的增殖。	Gene, 2022, 827:146460
S0924	Pteryxin	Pteryxin ((+)-Pteryxin) 是一種在 Apiaceae 傘形科中發(fā)現(xiàn)的二氫吡喃香豆素衍生物，也是一種有效的 butyrylcholinesterase (BChE) 的抑制劑，IC50值為12.96 μg/ml。Pteryxin 可抑制LPS誘導(dǎo)的小鼠腹膜巨噬細(xì)胞中 nitric oxide 的產(chǎn)生，其IC50值為20 μM。Pteryxin 具有治療阿爾茨海默氏病 (AD) 的潛力。
S9219	Huperzine B	Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.
S5886	Hodostin	Hodostin (Neostigmine methyl sulfate, Syntostigmin, Neostigmeth) 是acetylcholinesterase (AChE)的可逆性抑制劑，不能穿透血腦屏障，用于治療重癥肌無力。
S3246	Picfeltarraenin IB	Picfeltarraenin IB 是從 Picriafel-terrae 中分離出的葫蘆素糖苷，是 acetylcholinesterase (AChE) 的抑制劑。Picfeltarraenin IB 可用于治療皰疹感染，癌癥和炎癥。
S5663	Minaprine dihydrochloride	Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.
S9252	Corydaline	Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.
S5665	Drofenine Hydrochloride	Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers.
S9257	Acetylshikonin	Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.
S9260	Nodakenin	Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.
S3835	Loganin	Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
S4619	Itopride hydrochloride	Itopride hydrochloride (Ganaton, HSR803) 是一種AChE抑制劑。其IC50為2.04 +/- 0.27 μM。
S9463	Demecarium Bromide	Demecarium Bromide 是一種抗膽堿酯酶藥物，是單胺氧化酶 (MAO) 的抑制劑。它會引起長期瞳孔縮小，并降低血壓正常的比格犬和患有遺傳性青光眼的比格犬的眼睛的眼壓 (IOP)。
S3639	Tacrine hydrochloride hydrate	Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) 是膽堿酯酶（cholinesterase）抑制劑，可對抗骨骼肌松弛藥的作用，可作為呼吸興奮劑并用于治療阿茲海默病和其他中樞神經(jīng)系統(tǒng)障礙。它也是組胺N-甲基轉(zhuǎn)移酶（histamine N-methyltransferase）抑制劑。
S3769	Palmatine	Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.	Eur J Pharmacol, 2024, 967:176395
S9069	Jatrorrhizine chloride	Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
S9386	Polygalacic acid	Polygalacic acid 是從遠(yuǎn)志屬植物（Polygala paenea L.）分離出的三萜類四羥酸。Polygalacic acid (0-100μM; 24h) 可以顯著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表達(dá)，這些因子的表達(dá)由IL-1β誘導(dǎo)可顯著增加，并呈現(xiàn)出劑量依賴性。
S9087	Tenuifolin	Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.	CNS Neurosci Ther, 2025, 31(8):e70588
E7361	(±)-Huperzine A	(±)-Huperzine A 是傳統(tǒng)中草藥中提取的活性石松屬生物堿，是可逆的乙酰膽堿酯酶（ACE）抑制劑，在中國被廣泛的運用于阿爾茨海默病。
S3884	Jatrorrhizine	Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
E0905	N-p-trans-Coumaroyltyramine	N-p-trans-Coumaroyltyramine is an alpha-glucosidase inhibitor.
S3904	Isoimperatorin	Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities.
S9138	Picfeltarraenin IA	Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
S9152	Epiberberine	Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
S9510	Protriptyline hydrochloride	Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake.
S4838	Acotiamide hydrochloride	Acotiamide Hydrochloride (YM-443, Z-338)是acotiamide的鹽酸形式，acotiamide是一種腸蠕動促進(jìn)劑。它是一種新型的、具有口服活性的、選擇性的AChE抑制劑。
S4575	Pralidoxime chloride	Pralidoxime chloride (2-PAM)是有機(jī)磷農(nóng)藥和一些化學(xué)制品的解毒劑。是AChE的重新激活劑。
S3809	Imperatorin	Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.	Pharmaceuticals (Basel), 2023, 10.3390/ph16111595 Metabolites, 2022, 13(1)3 Adv Sci (Weinh), 2020, 7(16):2000925
S1890	Nizatidine	Nizatidine是一種組胺H2受體拮抗劑，作用于AChE，IC50為6.7 nM。	Gastroenterology, 2022, 162(4):1210-1225 Calcif Tissue Int, 2021, 109(6):696-705 bioRxiv, 2021, 10.1101/2021.04.29.441931
S3701	Benactyzine hydrochloride	Benactyzine hydrochloride是中樞性毒蕈堿受體拮抗劑。在抑郁癥和相關(guān)焦慮的治療中，它被用作抗抑郁劑。
S4072	Decamethonium Bromide	Decamethonium Bromide是一種煙堿AChR部分激動劑和神經(jīng)肌肉阻斷劑。
E5819^New	Clozapine N-oxide dihydrochloride	Clozapine N-oxide dihydrochloride 是氯氮平的主要代謝產(chǎn)物。它可作為人類毒蕈堿受體 DREADD 的激動劑，對 M1 DREADD 的 pEC50 為 8.31。
S5868	DL-Menthol	DL-Menthol是D-和L-menthol的外消旋混合物。Menthol是一種共價有機(jī)化合物，可通過有機(jī)反應(yīng)合成或從薄荷油中提取。
E5819^New	Clozapine N-oxide dihydrochloride	Clozapine N-oxide dihydrochloride 是氯氮平的主要代謝產(chǎn)物。它可作為人類毒蕈堿受體 DREADD 的激動劑，對 M1 DREADD 的 pEC50 為 8.31。