Serotonin Transporter

Serotonin Transporter產(chǎn)品

• 所有產(chǎn)品(28)
• Serotonin Transporter抑制劑 (27)
• Serotonin Transporter調(diào)節(jié)劑 (1)
• 新Serotonin Transporter產(chǎn)品

目錄號(hào)	產(chǎn)品名	產(chǎn)品描述	文獻(xiàn)引用	實(shí)驗(yàn)數(shù)據(jù)
S1627	Nitazoxanide	Nitazoxanide是一種人工合成的nitrothiazolyl-salicylamide衍生物，是一種抗原蟲劑（作用于犬流感病毒，IC50為0.17 到0.21 μM）。Nitazoxanide 可調(diào)節(jié)自噬并抑制 mTORC1 信號(hào)傳遞。	iScience, 2025, 28(4):112218 Nat Commun, 2024, 15(1):8708 Mol Ther, 2024, S1525-0016(24)00340-X
S1336	Fluvoxamine (DU-23000) maleate	Fluvoxamine maleate (DU-23000, MK-264)是一種選擇性5-羥色胺再攝取抑制劑(SSRI)。	Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433 Cell Rep, 2024, 43(10):114818 Brain Res, 2024, 1838:149011
S4749	Citalopram HBr	Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一種抗抑郁劑，是一種常用于口服途徑的選擇性serotonin reuptake抑制劑，IC50為1.8 nM。	Cell Rep, 2024, 43(10):114818 Chem Biol Interact, 2024, 403:111246 Aging (Albany NY), 2021, 13(11):14729-14744
S3005	Paroxetine HCl	Paroxetine HCl (BRL-29060A, FG-7051)是SSRI類抗抑郁藥。	Adv Sci (Weinh), 2025, 12(33):e01981 Cell Rep, 2024, 43(10):114818 Nat Commun, 2022, 13(1):3034
S2084	Duloxetine HCl	Duloxetine HCl (LY-248686)是一種5-羥色胺-去甲腎上腺素再攝取抑制劑，Ki為4.6 nM，用于治療重度抑郁癥和廣泛性焦慮癥（GAD）。	Cancers (Basel), 2022, 14(19)4883 Drug Metab Dispos, 2015, 44(3):378-88 J Pharmacol Exp Ther, 2014, 349(3):402-7
S4053	Sertraline HCl	Sertraline HCl (CP-51974-1) 是一種5-HT抑制劑， Ki值為13 nM.	EMBO Mol Med, 2025, 17(4):625-644 Cell Rep, 2024, 43(10):114818 Antimicrob Agents Chemother, 2021, AAC.01146-20
S3183	Amitriptyline HCl	Amitriptyline HCl 是一種 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制劑，其Ki值分別為3.45 nM和13.3 nM。Amitriptyline HCl 還可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，對(duì)應(yīng)的Ki值分別是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一種三環(huán)抗抑郁藥物。	Environ Toxicol Chem, 2021, 10.1002/etc.5018 PLoS Pathog, 2020, 16;16(3):e1008341 Sci Rep, 2018, 8(1):15753
S1441	Venlafaxine HCl	Venlafaxine HCl(Wy 453 HCl)是一種5-羥色胺-去甲腎上腺素再攝取抑制劑（SNRI），用于治療重度抑郁癥，泛焦慮癥，急性焦慮癥以及社交恐懼癥。	Am J Cancer Res, 2024, 14(3):1087-1100 Nat Commun, 2020, 14;11(1):1825 Drug Metab Dispos, 2020, 48(10):1044-1052
S2541	Clomipramine HCl	Clomipramine HCl是一種三環(huán)抗抑郁藥，可有效抑制5-HT再攝取，IC50值為1.5 nM。鹽酸氯丙咪嗪用于抑郁癥、焦慮癥和強(qiáng)迫癥的研究。	Biomed Pharmacother, 2022, 153:113328 bioRxiv, 2020, 2020/9/20.4.7.30734
S4259	Vilazodone HCl	Vilazodone(EMD68843,SB659746A)是一個(gè)組合的五羥色胺再攝取特定抑制劑（SSRI）和5-HT1A受體的部分激動(dòng)劑，目前正在臨床評(píng)估抑郁癥的治療。	Cell Rep Med, 2024, 5(10):101777 Eur J Pharmacol, 2024, 985:177058 J Pain, 2019, 20(1):16.e1-16.e16
S5239	Paroxetine mesylate	Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.	Am J Cancer Res, 2022, 12(4):1465-1483 Anal Methods, 2021, 10.1039/d0ay02027c
S2282	Cinchonidine	Cinchonidine是一種生物堿，在有機(jī)化學(xué)中用于不對(duì)稱合成。	CNS Neurosci Ther, 2023, 10.1111/cns.14403 J Med Virol, 2019, 91(8):1440-1447
S4377	Imipramine HCl	Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).	Cancer Drug Resist, 2022, 5(3):612-624 Antioxidants (Basel), 2021, 10(6)956 Biomedicines, 2021, 9(9)1230
S6301	MPP+ iodide	MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) 是神經(jīng)毒素 MPTP 的代謝物，通過(guò)選擇性破壞黑質(zhì)中的多巴胺能神經(jīng)元 dopaminergic neurons，在動(dòng)物模型中引起帕金森病(PD)的癥狀。MPP+ iodide 在SH-SY5Y細(xì)胞中誘導(dǎo) autophagic cell death。MPP+ iodide 在多巴胺能(DA)神經(jīng)元中誘導(dǎo) dopamine transporter (DAT) 的外化，但在血清素(5-HT)神經(jīng)元中誘導(dǎo) serotonin transporter (SERT) 的內(nèi)化。	NPJ Parkinsons Dis, 2025, 11(1):3 Front Immunol, 2023, 14:1193081 Front Immunol, 2023, 14:1193081
S4113	Desvenlafaxine	Desvenlafaxine (WY 45233 Succinate)是一種5-羥色胺(5-HT)和去甲腎上腺素(NE)重吸收抑制劑，Ki值分別為40.2 nM和558.4 nM。	Am J Cancer Res, 2024, 14(3):1087-1100 Drug Metab Dispos, 2020, 48(10):1044-1052
S4064	Escitalopram Oxalate	Escitalopram Oxalate是一種選擇性的5-羥色胺(5-HT)重吸收抑制劑(SSRI)，Ki值為0.89 nM.	Proc Natl Acad Sci U S A, 2025, 122(10):e2420499122 Cell Rep, 2024, 43(10):114818 J Matern Fetal Neonatal Med, 2023, 36(1):2183468
S5947	Amitriptyline	Amitriptyline (MK-230, N-750, Ro41575) 是一種三環(huán)抗抑郁藥，具有止痛效果，被廣泛用于治療抑郁和神經(jīng)性疼痛。Amitriptyline 是一種 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制劑，其Ki值分別為3.45 nM和13.3 nM。Amitriptyline 還可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，對(duì)應(yīng)的Ki值分別是0.5 nM、7.31 nM、235 nM和287 nM。該產(chǎn)品呈膠狀。	Cancer Cell, 2025, 43(4):776-796.e14 Cancers (Basel), 2019, 11(12)
S4112	Desvenlafaxine Succinate hydrate	Desvenlafaxine Succinate hydrate (WY 45233) 是一種新型5-羥色胺(5-HT)轉(zhuǎn)運(yùn)蛋白 和去甲腎上腺素(NE)轉(zhuǎn)運(yùn)蛋白重吸收抑制劑，Ki值分別為40.2 nM和558.4 nM	Drug Metab Dispos, 2020, 48(10):1044-1052
S5858	Vilazodone	Vilazodone (EMD-68843, SB-659746A)是一種新型抗抑郁劑，具有選擇性5-HT再攝取抑制作用和部分5-HT1A受體激動(dòng)活性。Vilazodone與5-HT重吸收位點(diǎn)的結(jié)合親和力比與去甲腎上腺素和多巴胺位點(diǎn)結(jié)合親和力高。	J Pain, 2019, 20(1):16.e1-16.e16
S1869	Dapoxetine HCl	Dapoxetine HCl (LY-210448)是一種短效的，新型選擇性5-羥色胺再攝取抑制劑。
S3140	Milnacipran HCl	Milnacipran HCl能抑制去甲腎上腺素轉(zhuǎn)運(yùn)蛋白(NET)和五羥色胺轉(zhuǎn)運(yùn)蛋白(SERT)，其IC50分別是77 nM和420 Nm	Am J Cancer Res, 2024, 14(3):1087-1100
S5693	Levomilnacipran Hydrochloride	Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
E4887	Dapoxetine	Dapoxetine ((S)-(+)-Dapoxetine; LY-210448)是一種具有口服活性的選擇性血清素再攝取抑制劑（SSRI）。達(dá)泊西汀是一種短效SSRI，專門用于治療早泄（PE）。
S5655	Venlafaxine	Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485	Desipramine Hydrochloride	Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
E4898	Escitalopram	Escitalopram((S)-Citalopram), (S)-+ Citalopram))是一種選擇性血清素再攝取抑制劑(SSRI)，Ki值為0.89 nM。Escitalopram的結(jié)合親和力比其R(-)-對(duì)映體高出約30倍，并且對(duì)去甲腎上腺素轉(zhuǎn)運(yùn)體(NET)和多巴胺轉(zhuǎn)運(yùn)體(DAT)均具有選擇性。
E7756	Imipramine	Imipramine 可抑制Fascin1和血清素轉(zhuǎn)運(yùn)體，IC50為32 nM。它還具有抗腫瘤活性，并可誘導(dǎo)U-87MG膠質(zhì)瘤細(xì)胞的自噬性細(xì)胞死亡。	J Extracell Vesicles, 2025, 14(2):e70042
S5071	Duloxetine	Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S1627	Nitazoxanide	Nitazoxanide是一種人工合成的nitrothiazolyl-salicylamide衍生物，是一種抗原蟲劑（作用于犬流感病毒，IC50為0.17 到0.21 μM）。Nitazoxanide 可調(diào)節(jié)自噬并抑制 mTORC1 信號(hào)傳遞。	iScience, 2025, 28(4):112218 Nat Commun, 2024, 15(1):8708 Mol Ther, 2024, S1525-0016(24)00340-X
S1336	Fluvoxamine (DU-23000) maleate	Fluvoxamine maleate (DU-23000, MK-264)是一種選擇性5-羥色胺再攝取抑制劑(SSRI)。	Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433 Cell Rep, 2024, 43(10):114818 Brain Res, 2024, 1838:149011
S4749	Citalopram HBr	Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一種抗抑郁劑，是一種常用于口服途徑的選擇性serotonin reuptake抑制劑，IC50為1.8 nM。	Cell Rep, 2024, 43(10):114818 Chem Biol Interact, 2024, 403:111246 Aging (Albany NY), 2021, 13(11):14729-14744
S3005	Paroxetine HCl	Paroxetine HCl (BRL-29060A, FG-7051)是SSRI類抗抑郁藥。	Adv Sci (Weinh), 2025, 12(33):e01981 Cell Rep, 2024, 43(10):114818 Nat Commun, 2022, 13(1):3034
S2084	Duloxetine HCl	Duloxetine HCl (LY-248686)是一種5-羥色胺-去甲腎上腺素再攝取抑制劑，Ki為4.6 nM，用于治療重度抑郁癥和廣泛性焦慮癥（GAD）。	Cancers (Basel), 2022, 14(19)4883 Drug Metab Dispos, 2015, 44(3):378-88 J Pharmacol Exp Ther, 2014, 349(3):402-7
S4053	Sertraline HCl	Sertraline HCl (CP-51974-1) 是一種5-HT抑制劑， Ki值為13 nM.	EMBO Mol Med, 2025, 17(4):625-644 Cell Rep, 2024, 43(10):114818 Antimicrob Agents Chemother, 2021, AAC.01146-20
S3183	Amitriptyline HCl	Amitriptyline HCl 是一種 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制劑，其Ki值分別為3.45 nM和13.3 nM。Amitriptyline HCl 還可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，對(duì)應(yīng)的Ki值分別是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一種三環(huán)抗抑郁藥物。	Environ Toxicol Chem, 2021, 10.1002/etc.5018 PLoS Pathog, 2020, 16;16(3):e1008341 Sci Rep, 2018, 8(1):15753
S1441	Venlafaxine HCl	Venlafaxine HCl(Wy 453 HCl)是一種5-羥色胺-去甲腎上腺素再攝取抑制劑（SNRI），用于治療重度抑郁癥，泛焦慮癥，急性焦慮癥以及社交恐懼癥。	Am J Cancer Res, 2024, 14(3):1087-1100 Nat Commun, 2020, 14;11(1):1825 Drug Metab Dispos, 2020, 48(10):1044-1052
S2541	Clomipramine HCl	Clomipramine HCl是一種三環(huán)抗抑郁藥，可有效抑制5-HT再攝取，IC50值為1.5 nM。鹽酸氯丙咪嗪用于抑郁癥、焦慮癥和強(qiáng)迫癥的研究。	Biomed Pharmacother, 2022, 153:113328 bioRxiv, 2020, 2020/9/20.4.7.30734
S4259	Vilazodone HCl	Vilazodone(EMD68843,SB659746A)是一個(gè)組合的五羥色胺再攝取特定抑制劑（SSRI）和5-HT1A受體的部分激動(dòng)劑，目前正在臨床評(píng)估抑郁癥的治療。	Cell Rep Med, 2024, 5(10):101777 Eur J Pharmacol, 2024, 985:177058 J Pain, 2019, 20(1):16.e1-16.e16
S5239	Paroxetine mesylate	Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.	Am J Cancer Res, 2022, 12(4):1465-1483 Anal Methods, 2021, 10.1039/d0ay02027c
S2282	Cinchonidine	Cinchonidine是一種生物堿，在有機(jī)化學(xué)中用于不對(duì)稱合成。	CNS Neurosci Ther, 2023, 10.1111/cns.14403 J Med Virol, 2019, 91(8):1440-1447
S4377	Imipramine HCl	Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).	Cancer Drug Resist, 2022, 5(3):612-624 Antioxidants (Basel), 2021, 10(6)956 Biomedicines, 2021, 9(9)1230
S4113	Desvenlafaxine	Desvenlafaxine (WY 45233 Succinate)是一種5-羥色胺(5-HT)和去甲腎上腺素(NE)重吸收抑制劑，Ki值分別為40.2 nM和558.4 nM。	Am J Cancer Res, 2024, 14(3):1087-1100 Drug Metab Dispos, 2020, 48(10):1044-1052
S4064	Escitalopram Oxalate	Escitalopram Oxalate是一種選擇性的5-羥色胺(5-HT)重吸收抑制劑(SSRI)，Ki值為0.89 nM.	Proc Natl Acad Sci U S A, 2025, 122(10):e2420499122 Cell Rep, 2024, 43(10):114818 J Matern Fetal Neonatal Med, 2023, 36(1):2183468
S5947	Amitriptyline	Amitriptyline (MK-230, N-750, Ro41575) 是一種三環(huán)抗抑郁藥，具有止痛效果，被廣泛用于治療抑郁和神經(jīng)性疼痛。Amitriptyline 是一種 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制劑，其Ki值分別為3.45 nM和13.3 nM。Amitriptyline 還可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，對(duì)應(yīng)的Ki值分別是0.5 nM、7.31 nM、235 nM和287 nM。該產(chǎn)品呈膠狀。	Cancer Cell, 2025, 43(4):776-796.e14 Cancers (Basel), 2019, 11(12)
S4112	Desvenlafaxine Succinate hydrate	Desvenlafaxine Succinate hydrate (WY 45233) 是一種新型5-羥色胺(5-HT)轉(zhuǎn)運(yùn)蛋白 和去甲腎上腺素(NE)轉(zhuǎn)運(yùn)蛋白重吸收抑制劑，Ki值分別為40.2 nM和558.4 nM	Drug Metab Dispos, 2020, 48(10):1044-1052
S5858	Vilazodone	Vilazodone (EMD-68843, SB-659746A)是一種新型抗抑郁劑，具有選擇性5-HT再攝取抑制作用和部分5-HT1A受體激動(dòng)活性。Vilazodone與5-HT重吸收位點(diǎn)的結(jié)合親和力比與去甲腎上腺素和多巴胺位點(diǎn)結(jié)合親和力高。	J Pain, 2019, 20(1):16.e1-16.e16
S1869	Dapoxetine HCl	Dapoxetine HCl (LY-210448)是一種短效的，新型選擇性5-羥色胺再攝取抑制劑。
S3140	Milnacipran HCl	Milnacipran HCl能抑制去甲腎上腺素轉(zhuǎn)運(yùn)蛋白(NET)和五羥色胺轉(zhuǎn)運(yùn)蛋白(SERT)，其IC50分別是77 nM和420 Nm	Am J Cancer Res, 2024, 14(3):1087-1100
S5693	Levomilnacipran Hydrochloride	Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
E4887	Dapoxetine	Dapoxetine ((S)-(+)-Dapoxetine; LY-210448)是一種具有口服活性的選擇性血清素再攝取抑制劑（SSRI）。達(dá)泊西汀是一種短效SSRI，專門用于治療早泄（PE）。
S5655	Venlafaxine	Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485	Desipramine Hydrochloride	Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
E4898	Escitalopram	Escitalopram((S)-Citalopram), (S)-+ Citalopram))是一種選擇性血清素再攝取抑制劑(SSRI)，Ki值為0.89 nM。Escitalopram的結(jié)合親和力比其R(-)-對(duì)映體高出約30倍，并且對(duì)去甲腎上腺素轉(zhuǎn)運(yùn)體(NET)和多巴胺轉(zhuǎn)運(yùn)體(DAT)均具有選擇性。
E7756	Imipramine	Imipramine 可抑制Fascin1和血清素轉(zhuǎn)運(yùn)體，IC50為32 nM。它還具有抗腫瘤活性，并可誘導(dǎo)U-87MG膠質(zhì)瘤細(xì)胞的自噬性細(xì)胞死亡。	J Extracell Vesicles, 2025, 14(2):e70042
S5071	Duloxetine	Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S6301	MPP+ iodide	MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) 是神經(jīng)毒素 MPTP 的代謝物，通過(guò)選擇性破壞黑質(zhì)中的多巴胺能神經(jīng)元 dopaminergic neurons，在動(dòng)物模型中引起帕金森病(PD)的癥狀。MPP+ iodide 在SH-SY5Y細(xì)胞中誘導(dǎo) autophagic cell death。MPP+ iodide 在多巴胺能(DA)神經(jīng)元中誘導(dǎo) dopamine transporter (DAT) 的外化，但在血清素(5-HT)神經(jīng)元中誘導(dǎo) serotonin transporter (SERT) 的內(nèi)化。	NPJ Parkinsons Dis, 2025, 11(1):3 Front Immunol, 2023, 14:1193081 Front Immunol, 2023, 14:1193081