NMDA receptor 選擇性抑制劑 | 激動(dòng)劑 | 拮抗劑 | 調(diào)節(jié)劑

目錄號	產(chǎn)品名	產(chǎn)品描述	Selective / Pan	IC50 / Ki
S6907	Rapastinel (GLYX-13)	Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects.	Selective
S3203	D-Alanine	D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.	Selective
S3535	Deudextromethorphan (AVP-786)	Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist.	Selective
S5032	Mephenesin	Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.	Selective
S3624	Quinolinic acid	Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.	Selective
S5302	6-Methoxy-2-naphthoic acid	6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.	Selective
S5287	Tiletamine Hydrochloride	Tiletamine is a lipophilc and potent vetrinary anesthetic. It is also a NMDA receptor antagonist.	Selective
S4957	Linalool	Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.	Selective
S2857	(-)-Dizocilpine (MK 801) Maleate	(-)-Dizocilpine (MK 801, Dizocilpine, C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with K_i of 30.5 nM.	Selective	NMDA receptor, Ki: 30.5 nM
S2876	(+)-Dizocilpine (MK 801) Maleate	(+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with K_d of 37.2 nM in rat brain membranes.	Selective	NMDA receptor, Kd: 37.2 nM
S4091	Ifenprodil Tartrate	Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.	Selective	NMDA Receptor, IC50: 0.3 μM
S0509	NMDAR antagonist 1	NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.	Selective	NMDAR, IC50: 10000 nM
S4023	Procaine HCl	Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with K_D of 1.7 μM.	Selective	NMDA receptor, IC50: 0.296 mM
S1330	Felbamate	Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.	Selective	NMDAR, IC50: 1.8 mM
s4702	Sarcosine	Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.	Selective
S4719	Kynurenic acid	Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.	Selective
S3653	Spermidine trihydrochloride	Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).	Selective
S6731	Eliprodil (SL-820715)	Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM.	Selective
S2043	Memantine HCl	Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.	Selective
S1614	Riluzole (PK 26124)	Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.	Selective
S7072	NMDA (N-Methyl-D-aspartic acid)	NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.	Selective