| S8264 |
NVS-PAK1-1 |
NVS-PAK1-1 is a potent and selective allosteric p21-activated kinase 1 (PAK1) inhibitor with an IC50 of 5 nM. |
Selective |
PAK1, IC50: 5nM |
| S7093 |
IPA-3 |
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6). |
Selective |
PAK1, IC50: 2.5 μM |
| S7271 |
FRAX597 |
FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.
|
Pan |
PAK1, IC50: 8 nM |
| S7094 |
PF-3758309 |
PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model. |
Pan |
PAK1, Ki: 13.7 nM |
| S7807 |
FRAX486 |
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively. |
Pan |
PAK1, IC50: 14 nM |
| S7989 |
FRAX1036 |
FRAX-1036 is a potent and selective PAK inhibitor with biochemical potency (Ki) of 23.3 nM and 72.4 nM against PAK1 and PAK2. |
Pan |
PAK1, Ki: 23.3 nM |
