β-nicotinamide mononucleotide (NMN)

別名: β-NM, NMN 中文名稱：β-煙酰胺單核苷酸

目錄號(hào)：S5259 Purity: 99.93%

Nicotinamide mononucleotide (β-NM, NMN)是NAD+的關(guān)鍵前體之一，也是NAMPT反應(yīng)的產(chǎn)物，通過(guò)煙酰胺單核苷酸腺苷酸轉(zhuǎn)移酶轉(zhuǎn)化為NAD+。

β-nicotinamide mononucleotide (NMN) Chemical Structure

CAS: 1094-61-7

規(guī)格	價(jià)格	庫(kù)存
25mg	794.91	現(xiàn)貨
100mg	1613.43	現(xiàn)貨
500mg	4668.3	現(xiàn)貨
1g	8108.28	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次：純度： 99.93%

99.93

常與β-nicotinamide mononucleotide (NMN)一起在實(shí)驗(yàn)中被使用的化合物

Nicotinamide N-oxide

β-Nicotinamide Mononucleotide和Nicotinamide N-oxide是NAD+的前體。

Nicotinamide Riboside Chloride

β-Nicotinamide Mononucleotide和Nicotinamide Riboside Chloride在Sprague-Dawley大鼠中口服時(shí)不產(chǎn)生任何明顯損傷。

MDL-800

β-Nicotinamide Mononucleotide和MDL-800在體外和體內(nèi)促進(jìn)DNA修復(fù)、減輕SARS-CoV-2感染和疾病嚴(yán)重程度。

Padnarsertib (KPT 9274)

β-Nicotinamide Mononucleotide可針對(duì)KPT-9274誘導(dǎo)的細(xì)胞毒性提供保護(hù)。

Selisistat (EX 527)

Selisistat (EX527)逆轉(zhuǎn)β-Nicotinamide Mononucleotide對(duì)記憶功能障礙、炎癥和氧化損傷的保護(hù)作用。

β-nicotinamide mononucleotide (NMN)相關(guān)產(chǎn)品

相關(guān)產(chǎn)品	BAPTA-AM Rat IgG2b isotype control-InVivo Blebbistatin Methyl-β-cyclodextrin (MβCD) AP-III-a4 (ENOblock) Ursolic Acid Carbazochrome sodium sulfonate (AC-17) Osthole Dioscin 4-Methylumbelliferone (4-MU) NAD+ Ethidium bromide Pitstop 2 Sesamin Carbenoxolone Sodium L-Mimosine Bilobalide Formononetin Hesperidin GO-203 Ademetionine Azeliragon (TTP488) Dp44mT Coenzyme Q10 (CoQ10) Silibinin (NSC 651520) Morin Hydrate N6022 Chlorogenic Acid Chrysin Spermine Tetrahydrochloride Vitexin Sphingosine D-Lin-MC3-DMA (MC3) 2-NBDG Ethylenediaminetetraacetic acid Bergenin (+)-Fangchinoline Spermine Iba1 Rabbit Recombinant mAb (20S)Ginsenoside Rg2 Farrerol DMNQ NB 598 Evofosfamide (TH-302) Reboxetine mesylate Inosine Sodium Nitroprusside Dihydrate 5-hydroxytryptophan (5-HTP) Stigmasterol Acipimox Bromhexine HCl 2,2,2-Tribromoethanol Hydroxytyrosol N-Acetylneuraminic acid D-(+)-Trehalose dihydrate Quinacrine Dihydrochloride Dihydrate L-methionine ADP Oleanonic Acid Anethole trithione D-Mannose 2,4-Pyridinedicarboxylic acid Trimetazidine E7820 GSK805 Curcumin analog C1 MYLS22 Sulfopin EGCG Octaacetate 20R-Camptothecin BMS-986176 Sodium Picosulfate Disufenton sodium Troxipide Sucralose Sclareol Kinetin FH1 FPH1 Fudosteine 3-Indolebutyric acid (IBA) Esculin Azomycin β-Sitosterol (+)-Usniacin Molsidomine Cinnamic acid Glucosamine hydrochloride ATP5A1 Rabbit Recombinant mAb Tea polyphenol Orcinol glucoside Phloretic acid Swertiamarin Methyl protocatechuate L-Tryptophan Laminin beta 1 Rabbit Recombinant mAb DDIT3 Rabbit Recombinant mAb PKC theta Rabbit Recombinant mAb 2,4-Dihydroxyacetophenone 3-Indolepropionic acid DL-Citrulline 6-Chloropurine Helecin Dynamin 2 Rabbit Recombinant mAb β-Alanine Calcium D-saccharate tetrahydrate Ferritin Rabbit Recombinant mAb Sodium succinate Stevioside Behenic Acid NSI-189 Acetyl Resveratrol Pterostilbene Sinoacutine 5'-Adenylic acid Cyanidin-3-O-glucoside chloride 23-Hydroxybetulinic acid Dihydrotanshinone I Plantamajoside Anhydroicaritin Anemoside B4 Morin Irigenin Sinapine thiocyanate Pinoresinol diglucoside Toosendanin 2'-deoxyguanosine Diludine Octyl gallate Stearic acid Methyl Eugenol Ligustilide Senkyunolide A GSK4112 1,2-Propanediol 1-Methyl-2-pyrrolidone Acetamide L-Hydroorotic acid L-Tryptophanamide Hydrochloride N-Acetyl-L-methionine Ureidosuccinic acid Creatine monohydrate DL-Dopa Aminomalonic acid 1-Hydroxy-2-naphthoic acid 3-Hydroxybenzoic acid Epibrassinolide LTI-291 ML329 PMPA tetrasodium salt CTX-0294885 Cremophor EL SR8278 Brassinazole DTT (Dithiothreitol) HEPES PZ-2891 Deoxyaconitine (R)-(-)-JQ1 Enantiomer L-(-)-Glucose Itaconic acid Sodium nitroprusside (+)-JQ1 carboxylic acid Iron Dextran BRM/BRG1 ATP Inhibitor-1 (BRM014) β-Cyclodextrin N-Nitrosodiethylamine 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) 4-HNE (4-Hydroxynonenal) Rat IgG1 isotype control-InVivo Substance P TFA Ginsenoside Rg3 Polyinosinic acid-polycytidylic acid Phyllanthus Urinaria Extract Emlenoflast (MCC-7840) Achyranthes bidentata root Extract BZ1 Polybrene (Hexadimethrine Bromide) IM-54 EGTA Sodium Pyruvate	點(diǎn)擊展開(kāi)
相關(guān)化合物庫(kù)	FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 已知活性藥物庫(kù)-I 多樣性化合物母核庫(kù)	點(diǎn)擊展開(kāi)

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系	實(shí)驗(yàn)類型	給藥濃度	孵育時(shí)間	活性描述	文獻(xiàn)信息(PMID)
MC3T3-E1	Cell viability assay	0.1, 1, 10?mM	6 h	AlCl3-induced reduction of MC3T3-E1 cell viability was successfully recovered by NMN treatment.	30292833
HepG2	Cell viability assay	0.5 mM	48 h	NMN was able to restore reduced NAD concentrations but not cell viability after stimulation with palmitate.	28974242
HL60 cells	Function assay	80 mM		syrosingopine-metformin-treated HL60 cells grown in medium supplemented with NMN had a partial recovery in ATP levels	30540938
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生物活性

產(chǎn)品描述	Nicotinamide mononucleotide (β-NM, NMN)是NAD+的關(guān)鍵前體之一，也是NAMPT反應(yīng)的產(chǎn)物，通過(guò)煙酰胺單核苷酸腺苷酸轉(zhuǎn)移酶轉(zhuǎn)化為NAD+。

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗(yàn)信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06036355	Not yet recruiting	Postoperative Prevention of Tumor	Shanghai Cell Therapy Group Co.Ltd	September 30 2023	Early Phase 1
NCT05759468	Recruiting	Type2diabetes\|Diabetic Kidney Disease	Brigham and Women''s Hospital\|Boston Medical Center	April 13 2023	Phase 2
NCT05789355	Recruiting	Sickle Cell Disease	LGD\|CEN Biotech\|Assistance Publique Hopitaux De Marseille\|Etablissement Fran?ais du Sang	April 1 2023	Not Applicable
NCT04910061	Completed	Healthy Volunteers	Seneque SA\|Dicentra Inc.\|LGD	August 5 2021	Not Applicable

參考文獻(xiàn)
https://pubmed.ncbi.nlm.nih.gov/33609723/ https://pubmed.ncbi.nlm.nih.gov/34089817/

參考文獻(xiàn)

https://pubmed.ncbi.nlm.nih.gov/33609723/
https://pubmed.ncbi.nlm.nih.gov/34089817/