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結(jié)直腸癌

造模劑

Dextran sulfate sodium

獲批藥物

Irinotecan hydrochloride

Calcium folinate

Tipiracil hydrochloride

化療方案

CAPOX: Capecitabine; Oxaliplatin

FOLFIRI: Calcium folinate; 5-Fluorouracil; Irinotecan hydrochloride

FOLFIRI-BEVACIZUMAB: Calcium folinate; 5-Fluorouracil; Irinotecan hydrochloride; Bevacizumab

FOLFIRI-CETUXIMAB: Calcium folinate; 5-Fluorouracil; Irinotecan hydrochloride; Cetuximab

FOLFOX: Calcium folinate; 5-Fluorouracil; Oxaliplatin

FU-LV: 5-Fluorouracil; Calcium folinate

XELIRI: Capecitabine; Irinotecan hydrochloride

XELOX: Capecitabine; Oxaliplatin

FOLFIRINOX: Calcium folinate; 5-Fluorouracil; Irinotecan hydrochloride; Oxaliplatin

NCCN指南推薦 ^[1]

一線治療: Calcium folinate; Capecitabine; Bevacizumab; Panitumumab; Cetuximab

二線治療: Panitumumab; Nivolumab; Ipilimumab; Dostarlimab; Trastuzumab; Lapatinib; Trastuzumab-deruxtecan

三線治療: Trifluridine; Tipiracil hydrochloride

免疫檢查點抑制劑

PD-1: Balstilimab; Finotonlimab; Nivolumab; Ezabenlimab; Retifanlimab; Toripalimab; Tislelizumab; Serplulimab; Zimberelimab; Penpulimab; Sintilimab; Pembrolizumab; Spartalizumab; Budigalimab; Pidilizumab

PD-L1: Atezolizumab; Durvalumab; Avelumab; Adebrelimab; Sugemalimab

CTLA-4: Nurulimab; Zalifrelimab; Quavonlimab; Ipilimumab; Tremelimumab

抗血管生成

mAbs: Bevacizumab; Ramucirumab; Panitumumab

TKIs: Masitinib; Fruquintinib; Regorafenib; Apatinib; Cabozantinib

靶向療法 (A) ^[2]

EGFR: Necitumumab; Panitumumab; Nimotuzumab; Cetuximab; Demupitamab; Modotuximab; Pimurutamab; Imgatuzumab; Matuzumab; Zalutumumab

VEGF-A: Bevacizumab

TYMS: Varisacumab; Capecitabine; Raltitrexed; Floxuridine; 5-Fluorouracil; Folinic acid

TOP1: Irinotecan hydrochloride; SN-38; Rubitecan

KRAS G12C: Adagrasib; Sotorasib; Opnurasib; LY3537982; Divarasib

Tubulin: Paclitaxel; Verubulin hydrochloride; ABT-751

CEACAM5: Labetuzumab; Labetuzumab govitecan

靶向療法 (B) ^[2]

DNA: TMZ; Oxaliplatin; Lurbinectedin; Nimustine Hydrochloride; TRC102

HER2: Trastuzumab; Tucatinib; TAS0728

BRAF: Encorafenib

KRAS G12D: MRTX1133

VEGFR2: Semaxanib; Apatinib; Ramucirumab

ERK1/2: SCH772984; Ravoxertinib; Ulixertinib; Temuterkib; ASN007; MK-8353

SHP2: SHP099 Hydrochloride; Batoprotafib; RMC-4550; NSC87877

干細胞標(biāo)志物 ^[3]

Lgr5: Petosemtamab

EpCAM: Adecatumumab; Citatuzumab; Oportuzumab

Bmi1: PRT4165; PTC-209 HBr; PTC-028; Unesbulin

CD44: Bivatuzumab; Angstrom6

CD26: Begelomab

ALDH1: Disulfiram; NCT-501; CM10

相關(guān)化合物庫

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library

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