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胃癌

工具分子

造模劑: 1-Methyl-3-nitro-1-nitrosoguanidine; N-Nitroso-N-methylurea

染料: Indocyanine green; Toluidine Blue O; Isosulfan Blue

抗感染

抗幽門螺桿菌: Clarithromycin; Amoxicillin; Vonoprazan Fumarate; Auranofin; Auraptene; Fucoidan

抗EBV: NIBR189; Paederoside

獲批藥物

Doxorubicin (Adriamycin) Hydrochloride

Trastuzumab deruxtecan

Tipiracil hydrochloride

化療

單藥: Tegafur

FP: 5-Fluorouracil; Cisplatin

XP: Capecitabine; Cisplatin

FOLFOX: 5-Fluorouracil; Oxaliplatin

XELOX: Capecitabine; Oxaliplatin

SOX: Tegafur; Oxaliplatin

DCF: Docetaxel; Cisplatin; 5-Fluorouracil

DOS: Tegafur; Oxaliplatin; Docetaxel

CSCO指南推薦 ^[1]

一線治療: Trastuzumab; Pembrolizumab; Oxaliplatin; Capecitabine; Cisplatin; 5-Fluorouracil; Tegafur; Leucovorin (Folinic acid) Calcium Pentahydrate; Calcium Folinate; Nivolumab; Sintilimab; Tislelizumab; Docetaxel

二線治療: Docetaxel; Paclitaxel; Irinotecan; Nab-Paclitaxel; Ramucirumab; Pembrolizumab; Nivolumab; Disitamab; Apatinib (YN968D1) mesylate

免疫檢查抑制劑

PD-1: Nivolumab; Pembrolizumab; Camrelizumab; Spartalizumab; Cemiplimab; Sintilimab; Zimberelimab; Retifanlimab; Sasanlimab; Tislelizumab; Balstilimab

PD-L1: Avelumab; Atezolizumab; Durvalumab; Adebrelimab; Sugemalimab; Cosibelimab

CTLA-4: Ipilimumab; Tremelimumab

近期活躍藥物

胃癌干細(xì)胞 ^[2]

靶向GC干性: Apatinib; Retinoic acid; Trastuzumab; Cisplatin; Amlodipine; Verapamil HCl; Verteporfin; Ibuprofen; Metformin; Pantoprazole; Quercetin; Sulforaphane; Evodiamine; DAPT; Atractylenolide I; Genistein

靶向CSCs: Vantictumab; MK-0752; Vismodegib; Amcasertib

靶向-HER2

抑制劑: Lapatinib; Afatinib; Neratinib; Sapitinib; Poziotinib; Tucatinib

抗體: Trastuzumab; Pertuzumab

ADC: Trastuzumab deruxtecan; Trastuzumab Emtansine（T-DM1）; Disitamab vedotin; Trastuzumab MMAE

靶向治療(A) ^[3]

Claudin18.2: Zolbetuximab

TYMS: 5-Fluorouracil; Trifluridine; TAS-102; Folinic acid

Tubulin: Combretastatin A4; Ixabepilone; Vincristine sulfate

c-Met: Savolitinib; AMG 337; Onartuzumab; Tivantinib

DNA: Lurbinectedin; Oxaliplatin; Nimustine Hydrochloride; Cisplatin; Lomustine; Thiotepa; Proflavine

Topoisomerase: Irinotecan Hydrochloride Trihydrate; Doxorubicin; Topotecan HCl; Epirubicin HCl; Dxd

VEGFR: Apatinib (YN968D1) mesylate; Ramucirumab; Foretinib; Pazopanib; Sorafenib; Regorafenib; Fruquintinib

靶向治療(B)

EGFR: Nimotuzumab; Pimurutamab; Matuzumab

FGFR: Pemigatinib; Derazantinib; Bemarituzumab; Lirafugratinib

PARP1/2: Pamiparib; Niraparib tosylate; Veliparib; Venadaparib

NF-kB ^[4]: Bortezomib; Curcumin; DHA; (±)-Shikonin; Sulfasalazine; Zeaxanthin

WNT ^[5]: CHIR-99021; XAV-939; RCM-1; SKL2001

NOTCH ^[5]: DAPT; Crenigacestat

Hedgehog ^[5]: Itraconazole

PAK4 ^[6]: LCH-7749944; Padnarsertib; PF-3758309; FRAX486; FRAX1036

靶向治療(C)

HIPPO ^[7]: Verteporfin; Simvastatin; Metformin; Defactinib; PF-573228; Dasatinib

mTOR ^[8]: Everolimus; Vistusertib; GSK1059615; Rapamycin

AKT ^[8]: MK-2206 Dihydrochloride; Capivasertib; Ipatasertib; Osthole

PI3K ^[8]: Alpelisib; GSK2636771

PI3K/AKT/mTOR ^[8]: Pectolinarigenin; Thymoquinone; ABBV-744; Dactolisib; GSK1059615; Calycosin

HSP90 ^[8]: Luminespib

MMP ^[8]: Astaxanthin

相關(guān)化合物庫(kù)

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library

MAPK Inhibitor Library

PI3K/Akt Inhibitor Library

參考文獻(xiàn)

[1] The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023, EviMed.
[2] Rao, X, et al. Cells 2022, 11, 2828.
[3] Gastric Cancer, Synapse, zhihuiya.
[4] Li Yuan, et al. Chinese Journal of Practical Surgery. 2021,41(1):66-71.
[5] Rao X, et al. Cells. 2022 Sep 10;11(18):2828.
[6] Xueqiong Fu, et al. Biosci Rep 1 April 2014; 34 (2): e00094.
[7] Messina B, et al. Cell Death Dis. 2023 Jan 12;14(1):21.
[8] Morgos DT, et al. Int J Mol Sci. 2024 Feb 3;25(3):1848.

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