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卵巢癌

造模劑

N-Nitroso-N-methylurea

4-Vinylcyclohexene dioxide

卵巢癌類器官 ^[1] ^[2]

Sodium Pyruvate

獲批藥物

Cyclophosphamide

Doxorubicin (Adriamycin) Hydrochloride

Gemcitabine Hydrochloride

Niraparib tosylate

Rucaparib Camsylate

化療方案

BEP/PEB: Bleomycin sulfate; Etoposide; Cisplatin

CARBOPLATIN-TAXOL: Carboplatin; Paclitaxel

GEMCITABINE-CISPLATIN: Gemcitabine Hydrochloride; Cisplatin

JEB: Carboplatin; Etoposide; Bleomycin sulfate

VAC: Vincristine; Actinomycin D; Cyclophosphamide

VeIP: Vinblastine sulfate; Ifosfamide; Cisplatin

免疫檢查點(diǎn)抑制劑

PD-1: Pembrolizumab; Dostarlimab; Cemiplimab; Camrelizumab; Sintilimab; Nivolumab; Serplulimab

PD-L1: Atezolizumab; Durvalumab; Avelumab; Adebrelimab; Sugemalimab

CTLA-4: Nurulimab; Zalifrelimab; Quavonlimab; Ipilimumab; Tremelimumab

抗血管生成 ^[3]

VEGFR: Bevacizumab; Pazopanib; Cediranib; Lenvatinib; Regorafenib

FGFR: Sorafenib; Ponatinib; Nintedanib

Angiotensin: Angiotensin II human Acetate; Angiotensin; Olmesartan

Endothelin: Zibotentan; BQ-123; Ambrisentan

IL-6: Tocilizumab; Sarilumab; Methylprednisolone

IL-8: SB225002; Aprepitant

PDGFR: Crenolanib; Ripretinib

DNA修復(fù)相關(guān) ^[3]

PARP: Olaparib; Veliparib; Rucaparib; Niraparib

DNA Alkylator: Melphalan; Trabectedin; Oxaliplatin; Carboplatin; Cyclophosphamide Monohydrate

RAD51: Amuvatinib; RI-1; RS-1

BRCA1: Bractoppin

ATM: AZD0156; AZD1390; AZ32; KU-60019; KU-55933

鉑類相關(guān) ^[3]

鉑類敏感: Carboplatin; Paclitaxel; Gemcitabine Hydrochloride; Bevacizumab; Cediranib; Niraparib; Doxorubicin (Adriamycin) Hydrochloride; Trabectedin; Olaparib

鉑類耐藥: Paclitaxel; Bevacizumab; Doxorubicin (Adriamycin) Hydrochloride; Topotecan HCl; Cediranib

靶向療法 (A) ^[3] ^[4]

TP53: Pifithrin-α (PFTα) Hhydrobromide; Pifithrin-μ; PRIMA-1

HER2: Trastuzumab; Pertuzumab; Margetuximab; Trastuzumab deruxtecan; Trastuzumab Emtansine（T-DM1）; Disitamab vedotin; Trastuzumab MMAE

PI3K: LY294002; Wortmannin; Alpelisib; Copanlisib; Idelalisib

mTOR: Everolimus; Temsirolimus; OSI-027

MYC: 10058-F4; 10074-G5

KRAS G12D: MRTX1133; KRpep-2d; BI-2865

KRAS G12C: Adagrasib; Sotorasib; ARS-1620

靶向療法 (B) ^[3]

PTEN: VO-Ohpic trihydrate; bpV

MDM2: Nutlin-3; Nutlin-3a; Triptolide; (-)-Parthenolide

CA-125/MUC16: Oregovomab; Abagovomab; Sofituzumab; Sofituzumab vedotin

Notch: Crenigacestat; Limantrafin

BRAF: Sorafenib; Vemurafenib; Dabrafenib

CDK2: SNS-032; CVT-313; Milciclib

HSP90: Ganetespib; Apoptozole; NMS-E973

靶向療法 (C) ^[3]

ERBB3/HER3: Patritumab; Seribantumab; Lumretuzumab; Patritumab deruxtecan

FRalpha: Mirvetuximab; Farletuzumab; Mirvetuximab-MMAE

FOXM1: RCM-1; FDI-6

BRD4: ABBV-744; dBET6

AURKA: Alisertib; Tozasertib; MLN8054

SMARCA4: PFI-3; ACBI1; AU-15330

KLF5: ML264; SR18662

mAb & ADC

HER2: Trastuzumab; Pertuzumab; Margetuximab; Trastuzumab deruxtecan; Trastuzumab Emtansine（T-DM1）; Disitamab vedotin; Trastuzumab MMAE

CA-125/MUC16: Oregovomab; Abagovomab; Sofituzumab; Sofituzumab vedotin

ERBB3/HER3: Patritumab; Seribantumab; Barecetamab; Lumretuzumab; Patritumab deruxtecan

FRalpha: Mirvetuximab; Farletuzumab; Mirvetuximab-MMAE

相關(guān)化合物庫(kù)

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

DNA Damage/DNA Repair compound Library

Angiogenesis Related compound Library

MAPK Inhibitor Library

Stem Cell Differentiation Compound Library

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