| S1820 |
Clofibrate |
Clofibrate (Atromid-S)是一種纖維酸衍生物,用于治療Ⅲ型高脂蛋白血癥和嚴(yán)重的高甘油三酯血癥。 |
| S4199 |
Antazoline HCl |
Antazoline hydrochloride(Phenazoline hydrochloride)是具有抗膽堿能作用的第一代抗組胺藥,常用于緩解鼻塞和滴眼劑。Antazoline hydrochloride對Huh7細(xì)胞中的HBV DNA有顯著抑制作用,EC50為2.349 μmol/L。 |
| S5065 |
Ganciclovir sodium |
Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) 是ganciclovir的鈉鹽形式,ganciclovir 是一種合成的抗病毒嘌呤核苷類似物,具有抗病毒活性,尤其是針對巨細(xì)胞病毒(CMV)。 |
| S1805 |
Acetylcholine Chloride |
化合物Acetylcholine Chloride(ACh chloride)是一種神經(jīng)遞質(zhì),作用于包括人類在內(nèi)的許多生物的周圍神經(jīng)系統(tǒng)(PNS)和中樞神經(jīng)系統(tǒng)(CNS)。 |
| S2030 |
Flunarizine 2HCl |
Flunarizine 2HCl (KW-3149, R14950) 是一種二氫鹽酸鹽,抑制鈣離子通道,Ki為68 nM。 |
| S1711 |
Crotamiton |
Crotamiton用作殺疥螨(治療疥瘡) ,是一種止癢藥。 |
| S5326 |
Dolasetron |
Dolasetron(MDL-73147EF) is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors. |
| S5399 |
Chlorprothixene hydrochloride |
Chlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. |
| S5392 |
Mepivacaine |
Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia. |
| S5416 |
Metyrapone |
Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis. |
| S4642 |
Dolutegravir Sodium |
Dolutegravir Sodium (GSK-1349572A)是HIV整合酶抑制劑,IC50為2.7 nM。 |
| S1648 |
Cytarabine |
Cytarabine是一種抗代謝藥,也是DNA synthesis抑制劑,在野生型CCRF-CEM細(xì)胞中IC50為16 nM。Cytarabine 可誘導(dǎo)自噬和細(xì)胞凋亡。 |
| S5278 |
Tedizolid |
Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria. |
| S5238 |
Solifenacin (YM905) |
Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. |
| S5667 |
Fruquintinib (HMPL-013) |
Fruquintinib is a small molecule inhibitor with strong potency and high selectivity against VEGFR family. It inhibits VEGFR 1, 2, 3, with IC50 values of 33 nM, 35 nM and 0.5 nM, respectively and shows only weak inhibition of RET, FGFR-1 and c-kit kinases. |
| S5701 |
Alvimopan dihydrate (LY246736 dihydrate) |
Alvimopan (LY-246736)是一種有效的、相對非選擇性的opioid拮抗劑,對μ, δ 和 κ opioid receptors的Ki值分別為0.77、4.4和40 nM,選擇性比對其他胺類G蛋白偶聯(lián)受體高100倍以上 |
| S9500 |
Valbenazine tosylate |
Valbenazine tosylate (NBI-98854) is the tosylate salt of valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM). |
| S4848 |
Dalbavancin |
Dalbavancin是一種脂糖肽類抗生素,對革蘭氏陽性菌,如多種葡萄狀球菌,具有殺菌活性。 |
| S5737 |
Diclofenac Epolamine |
Diclofenac Epolamine (DHEP, DIEP, diclofenac hydroxyethylpyrrolidine) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. |
| S5674 |
Lodoxamide Tromethamine |
Lodoxamide Tromethamine (Alomide, Lodoxamidetromethamine) is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity. |