原料藥(僅用于科研)

目錄號	產(chǎn)品名	產(chǎn)品描述
S4021	Tolcapone	Tolcapone (Ro 40-7592) 是一種有效和選擇性的可逆硝基酚類兒茶酚-O-甲基轉移酶(COMT)抑制劑，K_i為30nM。
S4589	Amodiaquine dihydrochloride dihydrate	Amodiaquine在人紅細胞中是一種有效的、非競爭性的組胺N-甲基轉移酶抑制劑，其Ki值為18.6 nM。它也被用作抗瘧疾藥和消炎藥。
S7128	Tazemetostat (EPZ-6438)	Tazemetostat (EPZ-6438, E7438)是一種有效的，選擇性EZH2抑制劑，無細胞試驗中K_i 和 IC50分別為2.5 nM 和 11 nM，比作用于EZH1選擇性高35倍，比作用于14種其他HMT選擇性高4500多倍。
S8555	Asciminib (ABL001)	Asciminib (ABL001)是一種有效的、選擇性的ABL1變構抑制劑，Kd值為0.5-0.8?nM，與ABL1的十四酰口袋結合。
S1472	Safinamide Mesylate	Safinamide Mesylate (PNU-151774E, FCE28073)是Safinamide的甲磺酸鹽，是一種選擇性的且可逆的MAO-B抑制劑，IC50為98 nM，比作用于MAO-A選擇性高5918倍。Phase 3。
S4245	Sodium ascorbate	Sodium ascorbate（Sodium Vitamin C）作為抗氧化劑和酸度調節(jié)劑，在消除慢性和急性感染方面發(fā)揮重要作用。
S5077	Regorafenib (BAY-734506) Monohydrate	Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate 是一種新型口服的多重激酶抑制劑，對VEGFR1、小鼠VEGFR2、小鼠VEGFR3、PDGFR-β、Kit (c-Kit)、RET (c-RET)、RAF-1、B-RAF和B-RAF(V600E)的IC50分別為13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM。
S1311	Pamidronate Disodium	Pamidronate Disodium (CGP 23339AE) 為含氮的雙磷酸鹽類藥物，用于預防骨質疏松癥。Pamidronate Disodium是骨吸收因子的抑制劑。
S5739	Nebivolol	Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S5741	Quetiapine	Quetiapine(ICI204636) 是一種非典型的抗精神病藥，用于治療精神分裂癥、雙相情感障礙和重度抑郁癥。Quetiapine 是一種5-HT receptors 激動劑，對人 5-HT1A receptor 的pEC50值為4.77。Quetiapine 是一種 dopamine receptor 拮抗劑，對人 D2 receptor 的pIC50值為6.33。Quetiapine 對人 D2, HT1A, 5-HT2A, 5-HT2C receptor 具有中到高親和力，pKis值為7.23、5.74、7.54、5.55。
S1791	Bacitracin Zinc	Bacitracin(Zinc Bacitracin)是一種抗生素，能夠干擾C55-isoprenyl pyrophosphate的去磷酸化，C55-isoprenyl pyrophosphate是一種膜載體分子，參與轉運構成肽聚糖細菌細胞壁內(nèi)膜外部成分。Bacitracin抑制甲硫啡肽中Tyr的裂解，IC50為10 μM。
S7158	Abemaciclib (LY2835219) Mesylate	Abemaciclib mesylate是一種有效的，選擇性CDK4和CDK6抑制劑，無細胞試驗中IC50分別為2 nM和10 nM。Phase 3。
S5476	Rolapitant	Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
S5719	Ceftizoxime sodium	Ceftizoxime sodium(SKF-88373) is a semisynthetic cephalosporin antibiotic that is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
S4692	Succimer	Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.
S5656	Diphenylpyraline hydrochloride	Diphenylpyraline hydrochloride is the hydrochloride salt form of diphenylpyraline, which is an antihistamine used in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
S5301	Carglumic Acid	Carglumic Acid (arbamylglutamic acid, Carbamino-L-glutamic acid, Ureidoglutaric acid, N-Carbamylglutamate) is an orally active, synthetic structural analogue of N-acetylglutamate (NAG) and carbamoyl phosphate synthetase 1 (CPS 1) activator, with ammonia lowering activity.
S5735	Midodrine	Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5720	Glecaprevir	Glecaprevir(ABT-493) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication. It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.
S5718	Acrivastine	Acrivastine(BW825C) is an antihistamine medicine that relieves the symptoms of allergies.

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