| S5410 |
Chloramphenicol sodium succinate |
Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity. |
| S5071 |
Duloxetine |
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
| S5069 |
Dabrafenib Mesylate |
Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.7 nM, 5.2 nM and 6.3 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively. |
| S5341 |
Metroprolol succinate |
Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
| S5350 |
Cefpodoxime proxetil |
Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. |
| S5424 |
Carbaryl |
Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide and also a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. |
| S3861 |
Sodium Demethylcantharidate |
Demethylcantharidin (norcantharidin) is a synthetic analogue of cantharidin and has potent antitumor activity. |
| S5428 |
Promazine hydrochloride |
Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects. |
| S5229 |
Isosorbide dinitrate |
Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide)是異山梨醇(isosorbide)的二硝酸鹽形式,這是一種具有血管擴(kuò)張活性的有機(jī)硝酸鹽。Isosorbide Dinitrate 是一種用于心力衰竭、食道痙攣的藥物,用于治療和預(yù)防因沒有足夠的血液流向心臟而引起的胸痛。Isosorbide Dinitrate 可轉(zhuǎn)化為一氧化氮(NO),一種活性中間化合物,可激活 the enzyme guanylate cyclase (atrial natriuretic peptide receptor A)。 |
| S3944 |
VPA (Valproic acid) |
VPA (Valproic acid)是一種具有抗驚厥性質(zhì)的脂肪酸,可用于治療癲癇。它也是一種 histone deacetylase (HDAC) 抑制劑,正用于研究治療HIV和各種癌癥的方法。Valproic acid (VPA) 通過上調(diào) BNIP3 誘導(dǎo)自噬和線粒體自噬,并通過上調(diào) PGC-1α 來誘導(dǎo)線粒體的生物合成。Valproic acid (VPA) 可激活 Notch-1 信號傳遞。 |
| S2378 |
Butylscopolamine Bromide |
Butylscopolamine Bromide (Scopolamine Butylbromide,(-)-Scopolamine butylbromide, Hyoscine butylbromide)是一種外周性的抗毒蕈堿,抗膽堿的藥劑,用作腹部特定的解痙藥。 |
| S2284 |
Colchicine |
Colchicine是一種微管聚合抑制劑, IC50為3 nM。 |
| S3647 |
Mafenide Acetate |
Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. |
| S3649 |
Ceftazidime |
Ceftazidime(GR20263) is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. |
| S3659 |
Fludrocortisone acetate |
Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. |
| S3710 |
Fosfomycin calcium |
Fosfomycin (phosphomycin, phosphonomycin) 是一種殺菌劑,可通過使UDP-N-acetylglucosamine-3-enolpyruvyltransferase失活而一直細(xì)菌細(xì)胞壁形成。Fosfomycin可通過甘油磷酸鹽轉(zhuǎn)運蛋白進(jìn)入細(xì)胞壁。 |
| S3743 |
Oxiglutatione |
Oxiglutatione (Oxidized glutathione, Glutathione disulfide, GSSG, Bi(glutathion-S-yl)) 是谷胱甘肽的氧化二硫化形式,具有潛在的保護(hù)活性。 |
| S3749 |
Calcium gluconate monohydrate |
Calcium gluconate (Calcarea gluconica, Calcium gluconate anhydrous, Calcium D-gluconate, Calciofon, Glucobiogen)是維持正常神經(jīng)、肌肉和心臟功能所必需的元素或礦物質(zhì)。葡萄糖鈣可維持體內(nèi)鈣平衡,口服可阻止骨質(zhì)疏松。 |
| S3750 |
Sodium benzoate |
Sodium benzoate (Benzoic acid sodium salt)是一種防腐劑,被用作食品添加劑,在酸性條件下抑菌。 |
| S3751 |
Quinidine hemisulfate hydrate |
Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine)可抑制電壓依賴性鈉離子通道,同時也具有抗毒蕈堿和抗瘧疾活性。 |