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表觀遺傳

DNA甲基化

DNMTs: Decitabine; Azacitidine; GSK3685032; Bobcat339 hydrochloride; SGI-1027; EGCG; CM272; Zebularine; RG108; Thioguanine

TETs: Bobcat339 hydrochloride; 5-Hydroxymethylcytosine

PRC1/2: GSK126; EED226; PRT4165; UNC6852; X1 compound

EZH1/2: Tazemetostat; GSK126; Valemetostat; Lirametostat; GSK343

組蛋白甲基化

G9a/GLP: BIX-01294 trihydrochloride; Chaetocin; UNC0638; UNC0642; A-366; BRD4770

Menin-MLL: VTP50469; Revumenib; MI-503; MI-2; MI-3; MI-463

WDR5-MLL: OICR-9429; WDR5-0103

PTEFb/CDK9: Enitociclib; Atuveciclib

DOT1L: Pinometostat; EPZ004777; SGC 0946

PRC1/2: GSK126; EED226; PRT4165; UNC6852; X1 compound

EZH1/2: Tazemetostat; GSK126; Valemetostat; Lirametostat; GSK343

PHD Finger Domain: JIB-04; Amiodarone HCl; Z-JIB-04

組蛋白乙酰化

HAT: SGC-CBP30; A-485; C646; MG149; WM-1119

BET Bromodomain: (+)-JQ1; Molibresib; Birabresib; Mivebresib; Pelabresib

Non-BET Bromodomain: SGC-CBP30; I-BRD9; I-CBP112; BI-7273; MS7972

Class I HDACs: Romidepsin; RGFP966; Entinostat; Mocetinostat; PCI-34051

Class IIa HDACs: LMK-235; Tasquinimod; TMP195; TMP269; Sodium butyrate

Class IIb HDACs: Ricolinostat; Tubacin; Tubastatin A; CAY10603; TH34

Class III HDACs/Sirtuin: Selisistat; Resveratrol; Nicotinamide; Quercetin; SRT1720 HCl

Class IV HDACs: SIS17

組蛋白磷酸化

CDK: Palbociclib (PD-0332991) Hydrochloride; Abemaciclib; Ribociclib; Dinaciclib; Ro-3306

MAPK: Adezmapimod; SB202190; Doramapimod; Metformin Hydrochloride; Ralimetinib (LY2228820) dimesylate

Aurora Kinase: Barasertib-HQPA; Alisertib; SP600125; ZM 447439; Tozasertib

PKC: Staurosporine; GSK690693; Go 6983; Fasudil HCl; Sotrastaurin

JNK: Doramapimod; Metformin Hydrochloride; SP600125; JNK-IN-8; Metformin

S6 Kinase: Staurosporine; Bosutinib; H-89 Dihydrochloride; BI-D1870; LY2584702

PP2A: LB-100; DT-061; IQ-1; AMZ30

PP2B: Cyclosporin A

rRNA表達正向調(diào)控 ^[1]

SMARCA: PFI-3; SGC-SMARCA-BRDVIII

RNA Polymerases: BMH-21; VV116; Suramin sodium salt; Rifampin; Fidaxomicin; Foscarnet Sodium

p300/EP300: SGC-CBP30; CPI-637; JQAD1

HAT: SGC-CBP30; A-485; C646; MG149; WM-1119; NEO2734

G9a/GLP: BIX-01294 trihydrochloride; Chaetocin; UNC0638; UNC0642; A-366; BRD4770

rRNA表達負向調(diào)控 ^[2]

HDAC1/2: Romidepsin; Quisinostat (JNJ-26481585) Dihydrochloride; Mocetinostat; Domatinostat; Abexinostat; (-)-Parthenolide

DNMTs: Decitabine; Azacitidine; GSK3685032; Bobcat339 hydrochloride; SGI-1027; EGCG; CM272; Zebularine; RG108; Thioguanine

Writers ^[3]

DNMTs: Decitabine; Azacitidine; Bobcat339 hydrochloride; SGI-1027; EGCG; Zebularine

G9a/GLP: BIX-01294 trihydrochloride; Chaetocin; UNC0638; UNC0642; A-366; BRD4770

EZH1/2: Tazemetostat; GSK126; Valemetostat; Lirametostat; GSK343; EPZ005687

SMYD: LLY-507; BCI-121; AZ505

DOT1L: Pinometostat; EPZ004777; SGC 0946

PRMT: EPZ015666; Pemrametostat; GSK591; MS023; AMI-1; SGC707

HAT: SGC-CBP30; A-485; C646; MG149; WM-1119; NEO2734

Readers ^[3]

MBT Domain: UNC1215; UNC669; UNC-926

Chromodomain/CBX7: UNC3866

PHD Finger Domain: JIB-04; Amiodarone HCl; Z-JIB-04

BET Bromodomain: (+)-JQ1; Molibresib; Birabresib; Mivebresib; Pelabresib; BMS-986158; ZEN-3694

Non-BET Bromodomain: SGC-CBP30; I-BRD9; I-CBP112; BI-7273; MS7972

Erasers ^[3]

LSD1/KDM1A: SP2509; GSK2879552 Dihydrochloride; GSK-LSD1 2HCl; Ladademstat (ORY-1001) Dihydrochloride; OG-L002; Seclidemstat; Pulrodemstat (CC-90011) besylate

JMJD: GSK-J4 Hydrochloride; JIB-04; GSK J1; CPI-455 HCl; CP2; IOX1; ML324; Z-JIB-04

HDACs: Romidepsin; Vorinostat; Panobinostat; Quisinostat (JNJ-26481585) Dihydrochloride; Entinostat; Belinostat; VPA; Pracinostat; Mocetinostat

Sirtuin: Selisistat; Resveratrol; Nicotinamide; Quercetin; SRT1720 HCl; Sirtinol

相關(guān)化合物庫

Epigenetics Compound Library

Histone modification compound library

Human Transcription Factor Compound Library

Kinase Inhibitor Library

Methylation Compound Library

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