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細(xì)胞死亡

細(xì)胞凋亡 ^[1]

Bcl-2 Family: Venetoclax; Navitoclax; ABT-737; S63845; AZD5991; TW-37; Sabutoclax; BDA-366; Obatoclax

Caspase: Z-VAD-FMK; Emricasan; Q-VD-Oph; Dinaciclib; Belnacasan; Lenalidomide; Z-IETD-FMK; Z-DEVD-FMK; Ac-DEVD-CHO; Ac-FLTD-CMK

TRAIL: TIC10; Tunicamycin; TIC10 Analogue; Conatumumab; Mapatumumab

IAP: Birinapant; Xevinapant; BV-6; AZD5582; SM-164; LCL161; Sepantronium Bromide; Tolinapant; Berberine chloride; GDC-0152

MDM-2/p53: Nutlin-3a; Idasanutlin; Triptolide; RG-7112; (-)-Parthenolide; NVP-CGM097

壞死性凋亡 ^[2]

TNF-α: Lenalidomide; Necrostatin-1; Pomalidomide; Acetylcysteine; Vadimezan; QNZ; Aprepitant; (±)-Shikonin; Thalidomide; Apremilast

TLR: Hydroxychloroquine (HCQ) Sulfate; Chloroquine; Resatorvid; TLR2-IN-C29; E6446; Cu-CPT22; CU-T12-9; Ginsenoside Rb1

RIP1: Necrostatin-1; GSK2982772; GSK'963; RIPA-56; GSK'547; GSK3145095; Citronellol; GSK481

RIP3: GSK872; Mito-TEMPO; HS-1371; Resibufogenin; Citronellol

MLKL: Necrosulfonamide; URMC-099; Resibufogenin; GW806742X

HSP90: Tamoxifen; Tamoxifen Citrate

細(xì)胞焦亡 ^[3]

誘導(dǎo)劑: Paclitaxel; Cisplatin; Nigericin sodium salt; Lipopolysaccharides; Ivermectin; Cholesterol; Polyphyllin VI; DHA

NLRP3: MCC950 Sodium; Nigericin sodium salt; Dapansutrile; CY-09; BMS-986299; Procyanidin B2; NLRP3 Inflammasome Inhibitor I

Caspase-1: Belnacasan; Z-YVAD-FMK; Mulberroside A; Chelidonic acid

IL-18/1β: T-5224; 3-Deazaadenosine hydrochloride; AUDA; PKR-IN-C16; 5'-N-Ethylcarboxamidoadenosine; Ossirene; Ac-YVAD-cmk; Diacerein; A-740003; (3R,8S)-Falcarindiol

GSDMD: Ac-FLTD-CMK; Disulfiram; LDC7559; 2-Bromohexadecanoic acid

Caspase-4/5/11: Belnacasan; Ac-FLTD-CMK; Wedelolactone

自噬 ^[4]

誘導(dǎo)劑: Afatinib; Erlotinib; Linifanib; Saracatinib; Dactolisib; Rapamycin

Beclin/Vps34 Complex: LY294002; Wortmannin; 3-Methyladenine; Spautin-1

Vps34: SAR405; VPS34 inhibitor 1; PIK-III; VPS34-IN1; Autophinib

ULK1: GSK690693; KU-55933; MRT68921 HCl; ULK-101; SBI-0206965; LYN-1604; BL-918; MRT67307 HCl

ATG4B: NSC 185058

lysosomal抑制劑: Verteporfin; Hydroxychloroquine (HCQ) Sulfate; Chloroquine; ROC-325; Mefloquine HCl

PI3K Complex抑制劑: LY294002; Wortmannin; Pictilisib; Buparlisib

p110δ抑制劑: Idelalisib; P110δ-IN-1; acalisib; IPI-3063

鐵死亡 ^[5]

誘導(dǎo)劑: Lapatinib; Roxadustat; Simvastatin; CA3; FIN56; IKE; Sulfasalazine; ML 210; ML162; iFSP1; Piperazine Erastin; Ammonium ferric citrate

激活劑: RSL3; Erastin; Cisplatin; Sorafenib; Sorafenib tosylate; BAY 87-2243; Deferasirox

抑制劑: Ferrostatin-1; SB202190; Liproxstatin-1; Acetylcysteine; Deferoxamine mesylate; Rosiglitazone; Setanaxib; Curcumin; Rosiglitazone maleate; Bardoxolone Methyl; Linagliptin; Pioglitazone HCl; UAMC-3203; Zileuton; Troglitazone; icFSP1

銅死亡 ^[6]

輔助因子: (+)-α-Lipoic acid

螯合劑: Tetrathiomolybdate; GSH; Triethylenetetramine 2HCl; 8-Hydroxyquinoline; Penicillamine

銅離子載體: Elesclomol; Disulfiram; PDTC; Clioquinol; 3-Hydroxyflavone

ROS: MitoQ (Mitoquinone) Mesylate; Sodium oxamate; Acetylcysteine; Setanaxib; CA3; BI-D1870; Sodium Dichloroacetate; N-Acetylcysteine amide

GLS: Telaglenastat; BPTES; JHU-083; 6-Diazo-5-oxo-L-norleucine; JHU395; GK921; IACS-6274; UPGL00004

BCL2/BCL2L1: Venetoclax; Navitoclax; ABT-737; A-1331852; A-1155463 Dihydrochloride; TW-37; Obatoclax Mesylate; Sabutoclax

FDX1: Elesclomol

ATP7B: Tetrathiomolybdate

雙硫死亡 ^[7]

SLC7A11/xCT: HG106; Levobupivacaine; Anti-CD98

GLUT抑制: BAY-876; KL-11743

硫醇氧化劑: Diethylmaleate

還原劑: DTT; TCEP Hydrochloride

NADP+/NADPH: 2-Deoxy-D-glucose; BAY-876; KL-11743; Nicotinamide; Phenazine methosulfate; Ethylenediaminetetraacetic acid; D-Glucose 6-phosphate disodium salt

胱氨酸/葡萄糖: Acetylcysteine; N-Acetylcysteine amide; L-Cystine; 2-Deoxy-D-glucose; Dextrose; L-(-)-Glucose

染液: H2DCFDA; DAPI Dihydrochloride; Propidium Iodide; Hematoxylin; Thiazolyl Blue; Coomassie Blue R-250; Eosin Y Disodium

相關(guān)化合物庫(kù)

Apoptosis Compound Library

Autophagy Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Mitochondria-Targeted Compound Library

Oxidative Stress Compound Library

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